Hariharan H, Barnum D A
Can J Comp Med. 1974 Oct;38(4):437-42.
Minimal inhibitory concentration (M.I.C.) values as determined by an agar-plate-dilution method for 60 bacterial isolates, consisting of Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus of animal origin against 20 antimicrobial drugs are presented. Of all the drugs, gentamicin had the best in vitro antibacterial activity in terms of M.I.C. when considering all the species of organisms together, while spectinomycin had the least activity.An inoculum replicator was a convenient tool in carrying out the agar-plate-dilution method.A comparison of the M.I.C. values of 42 isolates of S. typhimurium with the results obtained by low level method and the Bauer-Kir-by method showed that with few exceptions, there is a general agreement.
本文展示了采用琼脂平板稀释法测定的60株细菌（包括鼠伤寒沙门氏菌、大肠杆菌、铜绿假单胞菌和动物源金黄色葡萄球菌）对20种抗菌药物的最低抑菌浓度（M.I.C.）值。在所有药物中，就M.I.C.而言，当综合考虑所有生物体种类时，庆大霉素具有最佳的体外抗菌活性，而壮观霉素的活性最低。接种物复制器是进行琼脂平板稀释法的便捷工具。将42株鼠伤寒沙门氏菌的M.I.C.值与通过低水平法和鲍尔-柯克比法获得的结果进行比较表明，除少数例外情况外，总体上是一致的。
