Goto Y, Seino Y, Taminato T, Kadowaki S, Chiba T, Note S, Imura H
Diabetes. 1979 May;28(5):457-9. doi: 10.2337/diab.28.5.457.
Somatostatin's release from the isolated rat pancreas was studied using a perfusion technique. Arginine at a concentration of 19 mM produced a biphasic increase in somatostatin release from the perfused rat pancreas. Both first and second phases of somatostatin's increase are significantly higher in the presence of 1 mM theophylline than in the absence of the drug. These results indicate the possible inclusion of the adenylate cyclase--cyclic AMP system in the regulatory mechanism of rat pancreatic somatostatin secretion.
采用灌注技术研究了生长抑素从离体大鼠胰腺中的释放情况。浓度为19 mM的精氨酸使灌注大鼠胰腺中生长抑素的释放呈双相增加。在存在1 mM茶碱的情况下，生长抑素增加的第一阶段和第二阶段均显著高于无该药物时。这些结果表明，腺苷酸环化酶 - 环磷酸腺苷系统可能参与大鼠胰腺生长抑素分泌的调节机制。
