Rabin D, Mueller G L, Lacy W W, Liljenquist J E
Diabetes. 1979 May;28(5):486-90. doi: 10.2337/diab.28.5.486.
We examined splanchnic metabolism of alanine in 15 normal males under three sets of conditions: infusion of saline (control studies); infusion of somatostatin (SRIF) (bihormonal deficiency of insulin and glucagon); and infusion of somatostatin plus insulin (selective glucagon deficiency). Net splanchnic alanine uptake (NSAU) remained stable over 2 h during infusion of saline. Infusion of SRIF was associated with a fall in estimated hepatic plasma flow (EHPF) whether or not insulin was infused concomitantly. With SRIF only, arterio-hepatic venous alanine differences increased such that NSAU remained stable over 2 h, despite the fall in EHPF. In contrast, with selective glucagon deficiency, NSAU fell significantly after 2 h, an effect consequent on a fall in EHPF and a delayed fall in arterio-hepatic venous (A-HV) alanine differences. Our studies are compatible with a role for basal glucagon in maintenance of splanchnic extraction of alanine in normal man. However, the SRIF-initiated fall in EHPF may exert an influence on A-HV alanine differences independent of changes in pancreatic hormone secretion.
我们在三组条件下研究了15名正常男性体内丙氨酸的内脏代谢情况：输注生理盐水（对照研究）；输注生长抑素（SRIF）（胰岛素和胰高血糖素双激素缺乏）；输注生长抑素加胰岛素（选择性胰高血糖素缺乏）。在输注生理盐水期间，2小时内内脏丙氨酸净摄取量（NSAU）保持稳定。无论是否同时输注胰岛素，输注SRIF均与估计肝血浆流量（EHPF）下降有关。仅使用SRIF时，肝动静脉丙氨酸差值增加，因此尽管EHPF下降，但NSAU在2小时内仍保持稳定。相比之下，在选择性胰高血糖素缺乏的情况下，2小时后NSAU显著下降，这是由于EHPF下降以及肝动静脉（A-HV）丙氨酸差值延迟下降所致。我们的研究结果表明，基础胰高血糖素在维持正常人体内脏对丙氨酸的摄取中发挥作用。然而，SRIF引发的EHPF下降可能对A-HV丙氨酸差值产生影响，而与胰腺激素分泌变化无关。
