Gardner D E
Br J Exp Pathol. 1974 Oct;55(5):453-7.
Intravenous administration of type D episilon toxin to mice causes severe, generalized, vascular endothelial damage and progressive brain oedema. The brain oedema is revealed as a quantitive increase in the water content of brain tissue and a swelling of protoplasmic astrocytes and astrocytic processes around blood vessels and in the neuropil. The use of horse radish peroxidase as a tracer has indicated that the endothelial damage may also allow proteins to escape from the vascular lumen into the extracellular spaces of the brain. The suitability of type D epsilon toxin intoxication as a model for studying brain oedema and related problems is discussed.
给小鼠静脉注射D型ε毒素会导致严重的全身性血管内皮损伤和进行性脑水肿。脑水肿表现为脑组织含水量定量增加，血管周围和神经纤维网中细胞质星形胶质细胞及其突起肿胀。使用辣根过氧化物酶作为示踪剂表明，内皮损伤还可能使蛋白质从血管腔逸出到脑的细胞外间隙。本文讨论了D型ε毒素中毒作为研究脑水肿及相关问题模型的适用性。
