Pemler K, Penth B, Adams H J
Fortschr Med. 1979 Jun 7;97(21):1019-22.
513 patients with chronic ulcers of the leg were treated with Trental 400 orally in addition to local therapy. Regarding the reduction of the symptoms: ulcer extension, coldness of the leg, paraesthesia, resting pain and improvement of walking distance, 215 patients were classified as considerably improved, 195 distinctly improved, 53 slightly improved and 44 unchanged. Four cases worsened, two cases could not be classified. The possibility of combining oral therapy with local treatment and surgical measures (skin-flaps) is shown in three case reports. Gastro-intestinal tolerance of Trental 400 was good, interactions with concomitantly administered drugs were not reported.
513例腿部慢性溃疡患者除接受局部治疗外，还口服400毫克己酮可可碱进行治疗。关于症状减轻情况：溃疡扩展、腿部发冷、感觉异常、静息痛以及步行距离改善，215例患者被归类为显著改善，195例明显改善，53例略有改善，44例无变化。4例病情恶化，2例无法分类。三个病例报告展示了口服治疗与局部治疗及手术措施（皮瓣）联合应用的可能性。400毫克己酮可可碱的胃肠道耐受性良好，未报告与同时服用药物的相互作用。
