胰高血糖素刺激的灌注大鼠肝脏中的核蛋白激酶活性
Nuclear protein kinase activity in glucagon-stimulated perfused rat livers.
作者信息
Palmer W K, Castagna M, Walsh D A
出版信息
Biochem J. 1974 Nov;143(2):469-71. doi: 10.1042/bj1430469.
Abstract
Nuclei isolated from glucagon-stimulated perfused rat livers contained 2-3 times as much protein kinase activity as did nuclei from control animals. In the presence of either the heat-stable inhibitor or the protein kinase regulatory subunit the elevated cyclic AMP-independent enzyme activity from stimulated nuclei was inhibited to an activity equivalent to that found in controls.
摘要
从胰高血糖素刺激的灌注大鼠肝脏中分离出的细胞核所含的蛋白激酶活性是对照动物细胞核的2至3倍。在存在热稳定抑制剂或蛋白激酶调节亚基的情况下，受刺激细胞核中升高的不依赖环磷酸腺苷的酶活性被抑制至与对照中发现的活性相当的水平。
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