A1-(2-硝基-4-三甲基铵苯基)胰岛素的受体结合研究
Receptor binding studies on A1-(2-nitro-4-trimethylammoniophenyl)insulin.
作者信息
Lesniak M, Gliemann J, Roth J, Easter B R, Sutton D A, Drewes S E
出版信息
Hoppe Seylers Z Physiol Chem. 1979 Mar;360(3):467-71. doi: 10.1515/bchm2.1979.360.1.467.
PMID:437696
Abstract
The results are presented from receptor binding studies and isolated fat cell assays on A1-(2-nitro-4-trimethylammoniophenyl)insulin. In the former tests, the derivative is shown to have properties similar to native insulin and the fat cell assays afford a value of 76 +/- 4%. The importance of a charged, hydrophilic moiety attached at A1-glycine is discussed in the light of the above findings.
摘要
本文展示了对A1-（2-硝基-4-三甲基铵苯基）胰岛素进行受体结合研究和分离脂肪细胞测定的结果。在前一项测试中，该衍生物表现出与天然胰岛素相似的特性，脂肪细胞测定得出的值为76±4%。根据上述研究结果，讨论了连接在A1-甘氨酸上的带电荷亲水性部分的重要性。
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