Experimental induction of immune sialadenitis in guinea-pigs using different adjuvants.

Groups of guinea-pigs were immunized with a saline extract of salivary gland combined with different adjuvants, either alone or in combination. Periductal inflammatory infiltrates were most commonly induced when two adjuvants were given in combination, whereas they were unusual when given alone. The severest degrees of sialadenitis were seen when carbonyl iron and vaccine were used together. The results suggest that this may be a useful model for the study of autoimmune sialadenitis.