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[放射性胶体金预防乳腺癌术后胸膜复发的进一步事实]

[Further facts in pleural recurrence prevention by radio-colloidal gold in operated breast cancer].

作者信息

Sattler A

出版信息

Osterr Z Erforsch Bekampf Krebskr. 1970;25(1):6-23.

PMID:4378074
Abstract

The communication deals with endoscopical facts making recognizable that the intrapleural incorporation of colloidal radio-gold after the so-called radical mastectomy corresponds to a preventive-curative act. There is an analysis and proof of lymphogenous nature of the threatening, in it's manifest stage always lethal early and late pleural metastasis. The special and various features of the pleural cavity in postoperative endoscopy are demonstrated as a basis for the following dosage of radio-gold in a preventive-curative sense. Original, spectacular pictures are represented. On the basis of an experience for decades and because of the insufficient results of surgical therapy and conventional radiotherapy, unsatisfactory quoad sanationem et vitam, it must be pointed out that an additional, intrapleural radio-gold therapy is imperative. The application must be done early after operation. The effectiveness of this application is beyond question, since the pioneer-work of J. H. Müller and the ten years results with his preoperative radio-gold infiltration of the breast and my own endoscopically developed intrapleural radio-gold infusion. Both methods make possible true healing and ten years survival. For this reasons I recommend the employ of the more practicable intrapleural infusion on a big collective. The question of a long-term effectiveness of the therapy with fast electrons (betatron) is still to be decided on the ten years parameter. But I don't doubt that radio-gold is superior to all kind of radiotherapy controlling the contralateral pleural dissemination.

摘要

该通讯探讨了内窥镜检查结果,这些结果表明在所谓的根治性乳房切除术后胸膜腔内注入胶体放射性金相当于一种预防治疗行为。对具有威胁性的、在其明显阶段往往早期和晚期均致命的胸膜转移的淋巴源性本质进行了分析和论证。展示了术后内窥镜检查中胸膜腔的特殊和多样特征,作为从预防治疗角度确定放射性金后续剂量的依据。呈现了原始的、引人注目的图片。基于数十年的经验,以及手术治疗和传统放射治疗效果不佳(在治愈和生存方面均不尽人意),必须指出,额外的胸膜腔内放射性金治疗势在必行。该应用必须在术后早期进行。这种应用的有效性毋庸置疑,因为J. H. 米勒的开创性工作以及他术前对乳房进行放射性金浸润的十年成果,还有我在内窥镜下开展的胸膜腔内放射性金输注。这两种方法都能实现真正的治愈和十年生存。基于这些原因,我建议在大量人群中采用更实用的胸膜腔内输注方法。关于快速电子(电子加速器)治疗的长期有效性问题仍有待根据十年参数来决定。但我毫不怀疑放射性金在控制对侧胸膜播散方面优于所有类型的放射治疗。

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