Sheehan M, Haythorn P
Clin Biochem. 1979 Dec;12(6):262-3. doi: 10.1016/s0009-9120(79)80122-8.
A prospective study of 181 patients suspected of having liver disease was carried out to determine the relative efficiencies of serum bilirubin (total and direct), alkaline phosphatase (AP), gamma glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) with respect to diagnosis. Liver biopsies, liver scans, abdominal ultrasound, and clinical parameters were also tabulated and used independently to evaluate the patient's hepatic status and to determine the final diagnoses in each case. From the results of these tests for the 60 patients who were diagnosed as having liver disease, and the 87 patients who were felt to be free of liver disease, predictive values of the above tests were established. Data from this study suggests that while direct bilirubin is the most specific test, GGT is the most sensitive and has the fewest false negatives in the diagnosis of liver disease.
对181例疑似患有肝脏疾病的患者进行了一项前瞻性研究，以确定血清胆红素（总胆红素和直接胆红素）、碱性磷酸酶（AP）、γ-谷氨酰转移酶（GGT）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）在诊断方面的相对效率。肝活检、肝脏扫描、腹部超声以及临床参数也被列表记录，并独立用于评估患者的肝脏状况以及确定每个病例的最终诊断。根据对60例被诊断患有肝脏疾病的患者以及87例被认为没有肝脏疾病的患者所进行的这些检查结果，确定了上述检查的预测价值。这项研究的数据表明，虽然直接胆红素是最具特异性的检查，但GGT在肝脏疾病诊断中是最敏感的，且假阴性最少。
