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α-羟酸氧化酶：在肾微体中的定位

Alpha-hydroxy acid oxidase: localization in renal microbodies.

作者信息

Allen J M, Beard M E

出版信息

Science. 1965 Sep 24;149(3691):1507-9. doi: 10.1126/science.149.3691.1507.

DOI:10.1126/science.149.3691.1507
PMID:4378513
Abstract

Differential and density equilibrium centrifugation have established the presence of alpha-hydroxy acid oxidase in microbodies of the kidney of the rat. The enzyme has been demonstrated in cells of the distal convoluted tubule by a microscopic cytochemical method. This enzyme, like certain others in microbodies, produces hydrogen peroxide.

摘要

差速离心和密度平衡离心已证实大鼠肾脏微体中存在α-羟酸氧化酶。通过显微细胞化学方法已在远曲小管细胞中证实了该酶的存在。这种酶与微体中的某些其他酶一样，会产生过氧化氢。

相似文献

1
Alpha-hydroxy acid oxidase: localization in renal microbodies.α-羟酸氧化酶：在肾微体中的定位
Science. 1965 Sep 24;149(3691):1507-9. doi: 10.1126/science.149.3691.1507.
2
The localization of alpha-hydroxy acid oxidase in renal microbodies.α-羟酸氧化酶在肾微体中的定位。
J Exp Zool. 1965 Dec;160(3):329-44. doi: 10.1002/jez.1401600310.
3
Preparation and characterization of catalase-positive particles ('microperoxisomes') from Harder's gland of the rat.大鼠哈德氏腺过氧化氢酶阳性颗粒（“微过氧化物酶体”）的制备与表征
Exp Cell Res. 1975 Jan;90(1):15-9. doi: 10.1016/0014-4827(75)90351-1.
4
The cytochemical demonstration of catalase and D-amino acid oxidase in the microbodies of teleost kidney cells.硬骨鱼肾细胞微体中过氧化氢酶和D-氨基酸氧化酶的细胞化学显示
Histochem J. 1977 Mar;9(2):171-81. doi: 10.1007/BF01003629.
5
D-aspartate oxidation by rat and bovine renal peroxisomes: an electron microscopic cytochemical study.
J Histochem Cytochem. 1990 Sep;38(9):1377-81. doi: 10.1177/38.9.1974901.
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Peroxisomal oxidases: cytochemical localization and biological relevance.过氧化物酶体氧化酶：细胞化学定位及生物学意义
Prog Histochem Cytochem. 1989;20(1):1-65. doi: 10.1016/s0079-6336(89)80008-7.
7
[Effect of minimal hepatectomy on catalase and peroxisomal oxidase activity in rat liver].[次全肝切除术对大鼠肝脏过氧化氢酶和过氧化物酶体氧化酶活性的影响]
Biochimie. 1973;55(11):1491-4.
8
[Electron microscopic and enzyme histochemical findings in the efferent lymph vessels in the small intestine mesentery of the rat].[大鼠小肠系膜输出淋巴管的电子显微镜及酶组织化学研究结果]
Z Zellforsch Mikrosk Anat. 1969;101(3):338-54.
9
Light microscopical detection of H2O2-generating oxidases using cerium ions and aqueous incubation media.使用铈离子和水性孵育介质通过光学显微镜检测产生过氧化氢的氧化酶。
Acta Histochem. 1991;90(1):27-37. doi: 10.1016/S0065-1281(11)80153-4.
10
Peroxisomal function in perfused liver as studied by organ photometry.通过器官光度法研究灌注肝脏中的过氧化物酶体功能。
Ann N Y Acad Sci. 1982;386:153-64. doi: 10.1111/j.1749-6632.1982.tb21413.x.

引用本文的文献

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Structure of lactate oxidase from Enterococcus hirae revealed new aspects of active site loop function: Product-inhibition mechanism and oxygen gatekeeper.从海氏肠球菌中揭示出乳酸氧化酶的结构揭示了活性位点环功能的新方面：产物抑制机制和氧门卫。
Protein Sci. 2022 Oct;31(10):e4434. doi: 10.1002/pro.4434.
2
Developmental studies inDrosophila : V. Alkaline phosphatases, dehydrogenases and oxidases in organs and whole-fly homogenates during development ofD. pseudoobscura.果蝇的发育研究：V. 拟暗果蝇发育过程中器官及全蝇匀浆中的碱性磷酸酶、脱氢酶和氧化酶
Wilhelm Roux Arch Entwickl Mech Org. 1973 Dec;173(4):346-354. doi: 10.1007/BF00575839.
3
Response of hepatic microbodies to a hypolipidemic agent, ethyl chlorophenoxyisobutyrate (CPIB).
肝脏微体对降血脂药氯苯丁酯（CPIB）的反应。
J Cell Biol. 1966 Aug;30(2):442-50. doi: 10.1083/jcb.30.2.442.
4
Identification of clones of mammalian cells by isoenzyme distribution patterns.
Experientia. 1971 Jan 15;27(1):37-9. doi: 10.1007/BF02137728.
5
Cytochemical localization by ferricyanide reduction of -hydroxy acid oxidase activity in peroxisomes of rat kidney.用铁氰化物还原法对大鼠肾脏过氧化物酶体中α-羟酸氧化酶活性进行细胞化学定位。
Histochemie. 1971;27(2):137-58. doi: 10.1007/BF00284956.
6
Microbodies (peroxisomes) in the toad, Bufo marinus. A cytochemical study.海蟾蜍（Bufo marinus）中的微体（过氧化物酶体）。一项细胞化学研究。
Z Zellforsch Mikrosk Anat. 1970;108(2):135-49. doi: 10.1007/BF00335292.
7
Microbodies in experimentally altered cells.实验性改变细胞中的微体。
J Cell Biol. 1967 Oct;35(1):127-52. doi: 10.1083/jcb.35.1.127.
8
Studies on mouse liver urate oxidase. II. Immunochemical and enzymatic distribution of urate oxidase in mouse liver cell fractions.
Histochemie. 1973 Oct 26;37(2):149-59. doi: 10.1007/BF00305586.
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Particles resembling microbodies in normal and neoplastic perianal glands of dogs.犬正常和肿瘤性肛周腺中类似微体的颗粒。
Z Zellforsch Mikrosk Anat. 1968;90(4):554-62. doi: 10.1007/BF00339503.
10
Utilization of alpha-keto and alpha-hydroxy analogues of valine by the growing rat.生长中的大鼠对缬氨酸的α-酮类似物和α-羟基类似物的利用情况。
J Clin Invest. 1974 Aug;54(2):271-7. doi: 10.1172/JCI107762.