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Mechanism of metopirone inhibition of a soluble adrenal steroid 11-beta-hydroxylase.

作者信息

Williamson D G, O'Donnell V J

出版信息

Can J Biochem. 1967 Feb;45(2):153-63. doi: 10.1139/o67-018.

DOI:10.1139/o67-018
PMID:4381447
Abstract
摘要

相似文献

1
Mechanism of metopirone inhibition of a soluble adrenal steroid 11-beta-hydroxylase.美替吡酮对可溶性肾上腺类固醇11-β-羟化酶的抑制机制。
Can J Biochem. 1967 Feb;45(2):153-63. doi: 10.1139/o67-018.
2
MECHANISM OF INHIBITION OF ADRENAL STEROID 11BETA-HYDROXYLASE BY METHOPYRAPONE (METOPIRONE).甲吡酮（美替拉酮）对肾上腺类固醇11β-羟化酶的抑制机制
Endocrinology. 1963 Sep;73:304-9. doi: 10.1210/endo-73-3-304.
3
[Adrenal gland 21-hydroxylase from the domestic duck (Anas platyrhynchos)].[家鸭（绿头鸭）肾上腺21-羟化酶]
J Steroid Biochem. 1972 Jun;3(4):683-92. doi: 10.1016/0022-4731(72)90058-1.
4
A comparison of the effects produced by metyrapone and its reduced metabolitonheadrenal 11-beta-hydroxylase systm in the rat.甲吡酮及其代谢产物对大鼠肾上腺11-β-羟化酶系统作用的比较。
Steroids. 1970 Oct;16(4):401-13. doi: 10.1016/s0039-128x(70)80123-4.
5
The interaction of metopirone with adrenal mitochondrial cytochrome P-450. A mechanism for the inhibition of adrenal steroid 11 beta-hydroxylation.
Biochemistry. 1969 Apr;8(4):1306-11. doi: 10.1021/bi00832a003.
6
Steroid hydroxylation in bovine adrenocortical mitochondria. Competition between side-chain cleavage of cholesterol and 11 beta hydroxylation.牛肾上腺皮质线粒体中的类固醇羟基化。胆固醇侧链裂解与11β羟基化之间的竞争。
Biochemistry. 1971 Apr 13;10(8):1496-502.
7
Effect of polycyclic hydrocarbons on steroid 11 beta-hydroxylase activity of the adrenal in rats.多环烃对大鼠肾上腺类固醇11β-羟化酶活性的影响。
Cancer Res. 1968 Mar;28(3):559-63.
8
Significance of the steroid-induced type I spectral change in steroid C-21 hydroxylase system of bovine adrenocortical microsomes.
Arch Biochem Biophys. 1971 Dec;147(2):391-404. doi: 10.1016/0003-9861(71)90395-x.
9
The effect of steroid hydroxylase inhibitors on the rate of reduction of adrenal mitochondrial cytochrome P-450.类固醇羟化酶抑制剂对肾上腺线粒体细胞色素P-450还原速率的影响。
Biochem Biophys Res Commun. 1969 Aug 15;36(4):552-8. doi: 10.1016/0006-291x(69)90340-4.
10
Stereoselective inhibition of steroid 11-beta-hydroxylation in ox and sheep adrenocortical mitochondria: comparison of metyrapone and the enantiomers of 2-(4-aminophenyl)-2-phenethylamine (SKF-12185).牛和羊肾上腺皮质线粒体中甾体11-β-羟化的立体选择性抑制：美替拉酮与2-(4-氨基苯基)-2-苯乙胺（SKF-12185）对映体的比较
Biochem Pharmacol. 1973 Jul 1;22(13):1653-9. doi: 10.1016/0006-2952(73)90032-4.

引用本文的文献

1
Short-term kinetics of serum adrenal steroids and plasma ACTH after a single dose of metyrapone in man.
J Endocrinol Invest. 1980 Jul-Sep;3(3):229-36. doi: 10.1007/BF03348268.
2
[Accelerated oxidation of the 11 beta-hydroxy group in cortisol-11 alpha-T under stress conditions].[应激条件下皮质醇 - 11α - T中11β - 羟基的加速氧化]
Klin Wochenschr. 1967 Nov 15;45(22):1160-1. doi: 10.1007/BF01727402.
3
Experiments on the metyrapone reducing microsomal enzyme system.
Naunyn Schmiedebergs Arch Pharmakol. 1970;266(1):61-74. doi: 10.1007/BF00997783.
4
Kinetic experiments on the binding of metyrapone to liver microsomes.
Naunyn Schmiedebergs Arch Pharmakol. 1969;265(3):205-15. doi: 10.1007/BF01002335.