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Enzymatic conversion of a delta-4-3-ketosteroid into a 3-alpha-hydroxy-5-beta steroid: mechanism and stereochemistry of hydrogen transfer from NADPH. Bile acids and steroids 190.

作者信息

Berséus O, Björkhem L

出版信息

Eur J Biochem. 1967 Nov;2(4):503-7. doi: 10.1111/j.1432-1033.1967.tb00164.x.

DOI:10.1111/j.1432-1033.1967.tb00164.x
PMID:4384271
Abstract
摘要

相似文献

1
Enzymatic conversion of a delta-4-3-ketosteroid into a 3-alpha-hydroxy-5-beta steroid: mechanism and stereochemistry of hydrogen transfer from NADPH. Bile acids and steroids 190.将δ-4-3-酮甾体转化为3-α-羟基-5-β甾体：来自NADPH的氢转移机制和立体化学。胆汁酸与类固醇190
Eur J Biochem. 1967 Nov;2(4):503-7. doi: 10.1111/j.1432-1033.1967.tb00164.x.
2
Conversion of cholesterol to bile acids in rat: purification and properties of a delta-4-3-ketosteroid 5-beta-reductase and a 3-alpha-hydroxysteroid dehydrogenase.大鼠体内胆固醇向胆汁酸的转化：δ-4-3-酮甾体5-β-还原酶和3-α-羟基甾体脱氢酶的纯化及性质
Eur J Biochem. 1967 Nov;2(4):493-502. doi: 10.1111/j.1432-1033.1967.tb00163.x.
3
Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver.大鼠肝脏中δ-4-3-氧代甾体5-β-还原酶和3-α-羟基甾体脱氢酶催化的吡啶核苷酸氢转移的立体化学
Eur J Biochem. 1970 Jan;12(1):80-4. doi: 10.1111/j.1432-1033.1970.tb00823.x.
4
SYNTHESIS AND METABOLISM OF CHOLEST-4-ENE-7-ALPHA,12-ALPHA-DIOL-3-ONE AND 5-BETA-CHOLESTANE-7-ALPHA,12-ALPHA-DIOL-3-ONE. BILE ACIDS AND STEROIDS 153.胆甾-4-烯-7α,12α-二醇-3-酮与5β-胆甾烷-7α,12α-二醇-3-酮的合成与代谢。胆汁酸与类固醇153。
J Biol Chem. 1965 Jun;240:2396-401.
5
Stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5 beta-steroid. Bile acids and steroids 208.δ4-3-氧代甾体转化为3-氧代-5β-甾体的酶促反应的立体化学。胆汁酸与甾体208
Eur J Biochem. 1969 Jan;7(3):413-7. doi: 10.1111/j.1432-1033.1969.tb19625.x.
6
5 Beta-cholestane-3 alpha,7 alpha,12 alpha,26-tetrol:NAD+ oxidoreductase and 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol-26-al:NAD+ oxidoreductase in rat liver.
Biochim Biophys Acta. 1969 Jul 8;185(1):1-8. doi: 10.1016/0005-2744(69)90276-9.
7
Mechamism and stereochemistry of the enzymatic conversion of a delta 4-3-oxosteroid into a 3-oxo-5alpha-steroid.δ4-3-氧代甾体转化为3-氧代-5α-甾体的酶促反应机制及立体化学
Eur J Biochem. 1969 Apr;8(3):345-51. doi: 10.1111/j.1432-1033.1969.tb00534.x.
8
Stereochemistry of hydrogen transfer between pyridine nucleotide and some intermediates of cholesterol catabolism catalyzed by liver alcohol and aldehyde dehydrogenase.
Biochim Biophys Acta. 1974 Mar 21;341(1):48-55. doi: 10.1016/0005-2744(74)90064-3.
9
11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations.11β-羟基类固醇脱氢酶是大鼠肝细胞原代培养物中的一种独特的11β-还原酶：物理化学和激素处理的影响。
Endocrinology. 1995 Nov;136(11):4754-61. doi: 10.1210/endo.136.11.7588203.
10
Relationship between steroids and pyridine nucleotides in the oxido-reduction catalyzed by the 17 beta-hydroxysteroid dehydrogenase purified from the porcine testicular microsomal fraction.从猪睾丸微粒体部分纯化的17β-羟基类固醇脱氢酶催化的氧化还原反应中类固醇与吡啶核苷酸之间的关系。
Eur J Biochem. 1975 May 6;53(2):319-26. doi: 10.1111/j.1432-1033.1975.tb04071.x.

引用本文的文献

1
Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes.Δ4-3-氧代甾体 5β-还原酶缺乏症：口服胆汁酸治疗的反应和长期结果。
World J Gastroenterol. 2019 Feb 21;25(7):859-869. doi: 10.3748/wjg.v25.i7.859.
2
Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering.通过单点突变 E120H 将人固醇 5β-还原酶（AKR1D1）转化为 3β-羟甾脱氢酶：完美酶工程的实例。
J Biol Chem. 2012 May 11;287(20):16609-22. doi: 10.1074/jbc.M111.338780. Epub 2012 Mar 20.
3
Biosynthesis of bile acids in mammalian liver.
哺乳动物肝脏中胆汁酸的生物合成。
Eur J Drug Metab Pharmacokinet. 2006 Jul-Sep;31(3):145-56. doi: 10.1007/BF03190711.
4
Comparative anatomy of the aldo-keto reductase superfamily.醛酮还原酶超家族的比较解剖学
Biochem J. 1997 Sep 15;326 ( Pt 3)(Pt 3):625-36. doi: 10.1042/bj3260625.
5
Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.两种与十氯酮还原酶和胆汁酸结合剂相同的人肝脏3α-羟基类固醇/二氢二醇脱氢酶同工酶的分子克隆。
Biochem J. 1994 Apr 15;299 ( Pt 2)(Pt 2):545-52. doi: 10.1042/bj2990545.
6
[The primary hepatic synthesis of mono-hydroxy bile acids in extrahepatic biliary atresia (author's transl)].
Klin Wochenschr. 1973 Sep 15;51(18):926-32. doi: 10.1007/BF01468068.
7
The stereochemistry of hydrogen transfer from reduced nicotinamide-adenine dinucleotide phosphate in the reduction of ethylenic linkages during cholesterol biosynthesis.在胆固醇生物合成过程中，还原型烟酰胺腺嘌呤二核苷酸磷酸在烯键还原时氢转移的立体化学。
Biochem J. 1970 Oct;119(4):673-5. doi: 10.1042/bj1190673.
8
Cyclical oxidation-reduction of the C3 position on bile acids catalyzed by rat hepatic 3 alpha-hydroxysteroid dehydrogenase. I. Studies with the purified enzyme, isolated rat hepatocytes, and inhibition by indomethacin.大鼠肝脏3α-羟基类固醇脱氢酶催化胆汁酸C3位的循环氧化还原反应。I. 纯化酶、分离的大鼠肝细胞研究及吲哚美辛的抑制作用。
J Clin Invest. 1987 Sep;80(3):852-60. doi: 10.1172/JCI113143.
9
Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis.同卵双胞胎患新生儿肝炎时出现的δ4-3-氧代类固醇5β-还原酶缺乏症。胆汁酸合成中的一种新的先天性代谢缺陷。
J Clin Invest. 1988 Dec;82(6):2148-57. doi: 10.1172/JCI113837.
10
The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs.大鼠肝脏匀浆3α-羟基类固醇脱氢酶催化的动力学机制。含非甾体抗炎药的二元和三元终止复合物的证据。
Biochem J. 1991 Sep 15;278 ( Pt 3)(Pt 3):835-41. doi: 10.1042/bj2780835.