Schultz N R, Dineen J T, Elias M F, Pentz C A, Wood W G
J Gerontol. 1979 Mar;34(2):246-53. doi: 10.1093/geronj/34.2.246.
This study examined the effects of age and hypertension on WAIS performance. Previous studies have reported that hypertension adversely affects cognitive functioning, but few have considered the influence of hypertension on discrete age groups. Hypertension was found to be negatively associated with WAIS Verbal scores for younger (21 to 39 years) but not older (45 to 65 years) subjects. Further, younger subjects attained higher WAIS Performance scores than did older subjects. Medication history was not associated with performance levels for hypertensives, nor was performance of controls influenced by whether or not they were tested while on a diuretic. When WAIS Performance scores were analyzed for subjects matched on WAIS Verbal scores across age (21 to 39 vs 45 to 65 years) and blood pressure (normotensive vs hypertensive), a significant age by blood pressure interaction was found. The effect of blood pressure on Performance scores was found to be greater for younger than for older subjects. The association between plasma renin activity (PRA) level and WAIS Performance scores was also examined. Contrary to previous findings PRA was not related to Performance scores. The results are discussed in the context of previous hypertension research and their implications for comparisons across age levels.
本研究考察了年龄和高血压对韦氏成人智力量表（WAIS）测试表现的影响。以往研究报告称，高血压会对认知功能产生不利影响，但很少有研究考虑高血压对不同年龄组的影响。研究发现，高血压与年轻受试者（21至39岁）的WAIS言语分数呈负相关，但与年长受试者（45至65岁）无关。此外，年轻受试者的WAIS操作分数高于年长受试者。用药史与高血压患者的表现水平无关，对照组的表现也不受是否在服用利尿剂时接受测试的影响。当对年龄（21至39岁与45至65岁）和血压（血压正常与高血压）匹配的WAIS言语分数的受试者进行WAIS操作分数分析时，发现年龄与血压之间存在显著的交互作用。结果发现，血压对年轻受试者操作分数的影响大于年长受试者。还研究了血浆肾素活性（PRA）水平与WAIS操作分数之间的关联。与之前的研究结果相反，PRA与操作分数无关。研究结果将结合之前的高血压研究进行讨论，以及它们对不同年龄水平比较的影响。
