垂体切除或用溴隐亭治疗的山羊在怀孕期间的乳腺生长。

Mammary growth during pregnancy in hypophysectomized or bromocriptine-treated goats.

作者信息

Buttle H L, Cowie A T, Jones E A, Turvey A

出版信息

J Endocrinol. 1979 Mar;80(3):343-51. doi: 10.1677/joe.0.0800343.

DOI:10.1677/joe.0.0800343

Abstract

Mammogenesis in primiparous hypophysectomized goats has been assessed between days 60 and 120 of gestation and compared with that found in untreated goats and goats treated with 5 mg bromocriptine/day. There were fivefold increases in the weight of lobulo-alveolar tissue in the hypophysectomized and bromocriptine-treated goats and a tenfold increase in the untreated goats. Histological examination of the mammary glands at 120 days showed normal structure, and determinations of lactose, lactose synthetase, cytosol enzymes, protein, DNA and RNA indicated qualitatively normal initiation of milk synthetic capabilities in both the hypophysectomized and bromocriptine-treated goats. Bromocriptine treatment lowered the plasma concentration of placental lactogen as well as that of prolactin. The results indicate that placental lactogen has important mammogenic effects during pregnancy.

摘要

在妊娠60至120天期间，对初产垂体切除山羊的乳腺生成进行了评估，并与未治疗的山羊以及每天用5毫克溴隐亭治疗的山羊进行了比较。垂体切除和溴隐亭治疗的山羊小叶腺泡组织重量增加了五倍，未治疗的山羊增加了十倍。在120天时对乳腺进行组织学检查显示结构正常，乳糖、乳糖合成酶、胞质酶、蛋白质、DNA和RNA的测定表明，垂体切除和溴隐亭治疗的山羊在牛奶合成能力的启动方面在质量上是正常的。溴隐亭治疗降低了胎盘催乳素以及催乳素的血浆浓度。结果表明，胎盘催乳素在怀孕期间具有重要的乳腺生成作用。