在去极化的动脉平滑肌中，对钙和肾上腺素诱导的收缩进行阻断或逆转。
Blockade or reversal of the contraction induced by calcium and adrenaline in depolarized arterial smooth muscle.
作者信息
Godfraind T, Kaba A
出版信息
Br J Pharmacol. 1969 Jul;36(3):549-60. doi: 10.1111/j.1476-5381.1969.tb08010.x.
Abstract
- Mesenteric arteries immersed in a depolarizing solution contract in the presence of calcium. These contractions are proportional to the calcium concentration and are reversible.2. Mesenteric arteries immersed in a calcium-free depolarizing solution contract in the presence of adrenaline. Under the experimental conditions reported here, this response develops only about one-third of the contractile tension developed in polarizing solution (modified Krebs bicarbonate).3. Cinnarizine and chlorpromazine inhibit the contractile response to calcium and induce relaxation of depolarized muscle previously contracted by calcium; cinnarizine was 4 times more potent than chlorpromazine in such activity.4. Chlorpromazine inhibits the response to adrenaline in both polarizing and calcium-free depolarizing solutions, whereas cinnarizine inhibits the response in polarizing solution but not that in calcium-free depolarizing solution.5. The significance of these results is discussed.
摘要
浸于去极化溶液中的肠系膜动脉在有钙存在时会收缩。这些收缩与钙浓度成正比且是可逆的。
浸于无钙去极化溶液中的肠系膜动脉在有肾上腺素存在时会收缩。在此处报道的实验条件下，这种反应产生的收缩张力仅约为在极化溶液（改良的 Krebs 碳酸氢盐溶液）中产生的收缩张力的三分之一。
桂利嗪和氯丙嗪抑制对钙的收缩反应，并使先前因钙而收缩的去极化肌肉松弛；在此活性方面，桂利嗪的效力是氯丙嗪的 4 倍。
氯丙嗪在极化溶液和无钙去极化溶液中均抑制对肾上腺素的反应，而桂利嗪在极化溶液中抑制该反应，但在无钙去极化溶液中则不然。
讨论了这些结果的意义。
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Br J Pharmacol. 1969 Jul;36(3):549-60. doi: 10.1111/j.1476-5381.1969.tb08010.x.
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