醋酸氟氢可的松及其固体剂型的高效液相色谱分析。
Analysis of fludrocortisone acetate and its solid dosage forms by high-performance liquid chromatography.
作者信息
Ast T M, Abdou H M
出版信息
J Pharm Sci. 1979 Apr;68(4):421-3. doi: 10.1002/jps.2600680407.
PMID:438959
Abstract
A newly developed reversed-phase high-performance liquid chromatographic assay and test method for determining content uniformity are described for fludrocortisone acetate. The method is stability indicating and separates most known degradation products and impurities. In addition, the method is simple, sensitive, accurate, and relatively free of interferences. The coefficient of variation for multiple weight assays is between 0.3 and 1.8%.
摘要
描述了一种新开发的用于测定醋酸氟氢可的松含量均匀度的反相高效液相色谱测定法和测试方法。该方法具有稳定性指示功能，可分离大多数已知的降解产物和杂质。此外，该方法简单、灵敏、准确，且相对无干扰。多次称重测定的变异系数在0.3%至1.8%之间。
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