[关于1-亚硝基-3-硝基-1-甲基胍（NNMG）诱变作用的机制。IV. NNMG的稳定性、突变率与细胞对诱变剂摄取之间的关系以及巯基甲基化作为pH值函数的需求] - Suppr | 超能文献

[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine (NNMG) in mutagenesis. IV. Stability of NNMG, relations between mutation rate and uptake of the mutagen by the cell, and requirement for methylation by sulfhydryl groups as a function of the pH value].

作者信息

Süssmuth R, Lingens F

出版信息

Z Naturforsch B. 1969 Jul;24(7):903-10.

Abstract

摘要

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[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine (NNMG) in mutagenesis. IV. Stability of NNMG, relations between mutation rate and uptake of the mutagen by the cell, and requirement for methylation by sulfhydryl groups as a function of the pH value].[关于1-亚硝基-3-硝基-1-甲基胍（NNMG）诱变作用的机制。IV. NNMG的稳定性、突变率与细胞对诱变剂摄取之间的关系以及巯基甲基化作为pH值函数的需求]

Z Naturforsch B. 1969 Jul;24(7):903-10.

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[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine (NNMG) with respect to mutagenesis. 3. On the inhibition of nucleic acid synthesis and cell-free protein biosynthesis by NNMG and the appearance of resistant Escherichia coli cells after treatment with NNMG].[关于1-亚硝基-3-硝基-1-甲基胍（NNMG）的诱变作用机制。3. NNMG对核酸合成和无细胞蛋白质生物合成的抑制作用以及用NNMG处理后抗性大肠杆菌细胞的出现]

Z Naturforsch B. 1969 Jun;24(6):707-12.

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[On the optimum pH of mutation induction by 1-nitroso-3-nitro-1-methylguanide].[关于1-亚硝基-3-硝基-1-甲基胍诱导突变的最佳pH值]

Naturwissenschaften. 1968 Feb;55(2):85. doi: 10.1007/BF00599497.

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[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine in the induction of mutation. I. Effect of 1-nitroso-3-nitro-1-methylguanidine on the template activity of polyncleotides in cell-free protein synthesis].[关于1-亚硝基-3-硝基-1-甲基胍诱导突变的作用机制。I. 1-亚硝基-3-硝基-1-甲基胍对无细胞蛋白质合成中多核苷酸模板活性的影响]

Z Naturforsch B. 1967 May;22(5):512-7.

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[On the mechanism of action of 1-nitroso-3-nitro-1-methylguanidine during induced mutation. II. Products of the reaction of 1-nitroso-3-nitro-1-methylguanidine with nucleic bases, nucleosides, nucleosidephosphatesmand homopolyribonucleic acids].[关于1-亚硝基-3-硝基-1-甲基胍在诱导突变过程中的作用机制。II. 1-亚硝基-3-硝基-1-甲基胍与核酸碱基、核苷、核苷磷酸和同聚核糖核酸的反应产物]

Z Naturforsch B. 1968 Dec;23(12):1565-70.

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[Effects of 1-nitroso-3-nitro-1-methylguanidine on the cell-free protensynthesis in E. coli cells and the matrix activity of calf thymus DNA].[1-亚硝基-3-硝基-1-甲基胍对大肠杆菌无细胞蛋白质合成及小牛胸腺DNA模板活性的影响]

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Action of N-methyl-N'-nitro-N-nitrosoguanidine on transforming DNA of Bacillus subtilis.N-甲基-N'-硝基-N-亚硝基胍对枯草芽孢杆菌转化DNA的作用。

Mutat Res. 1970 Aug;10(2):85-90. doi: 10.1016/0027-5107(70)90152-1.

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Repair of DNA damaged by N-methyl-N'-nitro-N-nitrosoguanidine in Escherichia coli.大肠杆菌中由N-甲基-N'-硝基-N-亚硝基胍损伤的DNA修复

Mutat Res. 1967 May-Jun;4(3):369-71. doi: 10.1016/0027-5107(67)90031-0.

9

Diazomethane as the active agent in nitrosoguanidine mutagenesis and lethality.重氮甲烷作为亚硝基胍诱变和致死作用中的活性剂。

Mol Gen Genet. 1968 May 3;101(3):191-202. doi: 10.1007/BF00271621.

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[Obtaining auxotropic mutants from cultures of Escherichia coli pathogenic serotype O111:B4:H2, treated with N-methyl-N'-nitro-N-nitrosoguanidine].[从经N-甲基-N'-硝基-N-亚硝基胍处理的致病性血清型O111:B4:H2大肠杆菌培养物中获得营养缺陷型突变体]

Biull Eksp Biol Med. 1970 Feb;69(2):110-2.

引用本文的文献

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Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.SNQ3/YAP1基因的过表达通过一种不依赖谷胱甘肽的机制赋予酿酒酵母对亚硝基胍的超抗性。

Curr Genet. 1994 May;25(5):469-71. doi: 10.1007/BF00351788.

2

Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine.经不同途径给予N-甲基-N-亚硝基-N'-硝基胍和N-乙基-N-亚硝基-N'-硝基胍后大鼠和小鼠的胃肠道肿瘤

Br J Cancer. 1969 Dec;23(4):757-64. doi: 10.1038/bjc.1969.94.