右旋普萘洛尔在急性心肌梗死中的血流动力学效应
Haemodynamic effects of dextro-propranolol in acute myocardial infarction.
作者信息
Bennet D, Balcon R, Hoy J, Sowton E
出版信息
Thorax. 1970 Jan;25(1):86-8. doi: 10.1136/thx.25.1.86.
Abstract
Intravenous injections of 20-25 mg. d-propranolol did not change the heart rate or systemic pressure in 13 patients with cardiac infarction. Cardiac output was depressed in 10, but there was no clinical deterioration. d-Propranolol was better tolerated than dl-propranolol under these conditions and justifies further investigation as an anti-dysrhythmic agent. The major depressant effects of dl-propranolol following cardiac infarction appear to be due to beta-adrenergic blockade and not to a direct depressant action on cardiac muscle.
摘要
对13例心肌梗死患者静脉注射20 - 25毫克d-普萘洛尔，未改变其心率或体循环压力。10例患者的心输出量降低，但无临床病情恶化。在这些情况下，d-普萘洛尔比dl-普萘洛尔耐受性更好，有理由作为抗心律失常药物作进一步研究。dl-普萘洛尔在心肌梗死后的主要抑制作用似乎是由于β-肾上腺素能阻滞，而非对心肌的直接抑制作用。
相似文献
1
Haemodynamic effects of dextro-propranolol in acute myocardial infarction.右旋普萘洛尔在急性心肌梗死中的血流动力学效应
Thorax. 1970 Jan;25(1):86-8. doi: 10.1136/thx.25.1.86.
2
Intravenous therapy with propranolol in acute myocardial infarction: effects on changes in the S-T segment and hemodynamics.急性心肌梗死中普萘洛尔的静脉治疗：对S-T段变化和血流动力学的影响。
Chest. 1978 Nov;74(5):514-21. doi: 10.1378/chest.74.5.514.
3
Haemodynamic effects of selective beta-adrenergic blockade during acute stage of myocardial infarction.心肌梗死急性期选择性β-肾上腺素能阻滞剂的血流动力学效应
Br Heart J. 1972 Dec;34(12):1295-301. doi: 10.1136/hrt.34.12.1295.
4
Cardiovascular response in hyperthyroidism. The influence of adrenergic-receptor blockade.甲状腺功能亢进症中的心血管反应。肾上腺素能受体阻滞剂的影响。
Arch Intern Med. 1972 Mar;129(3):426-9.
5
6
The haemodynamic effects of atropine combined with propranolol in acute myocardial infarction.阿托品联合普萘洛尔在急性心肌梗死中的血流动力学效应。
Med J Aust. 1968 Mar 2;1(9):333-4. doi: 10.5694/j.1326-5377.1968.tb28539.x.
7
Effect of tolamolol versus propranolol on cardiovascular haemodynamics in patients with angina.托拉洛尔与普萘洛尔对心绞痛患者心血管血流动力学的影响。
Br Heart J. 1974 Nov;36(11):1078-81. doi: 10.1136/hrt.36.11.1078.
8
[Comparison of the hemodynamic effects in man of 2 beta-blockaders: propranolol and practolol].[两种β受体阻滞剂（普萘洛尔和醋氨心安）对人体血流动力学影响的比较]
Boll Soc Ital Cardiol. 1972;17(2):91-101.
9
Enhanced haemodynamic effects of propranolol in acute myocardial infarction.普萘洛尔在急性心肌梗死中的血流动力学效应增强
Eur Heart J. 1984 May;5(5):366-73. doi: 10.1093/oxfordjournals.eurheartj.a061670.
10
Haemodynamic effects of propranolol (Inderal) in acute myocardial infarction.普萘洛尔（心得安）在急性心肌梗死中的血流动力学效应。
Br Med J. 1967 Jan 21;1(5533):141-3. doi: 10.1136/bmj.1.5533.141.
引用本文的文献
1
Central haemodynamic effects in man of intravenous d-alprenolol during rest and exercise.静注d-心得舒对人体休息及运动时中心血流动力学的影响
Eur J Clin Pharmacol. 1971 Sep;3(4):198-203. doi: 10.1007/BF00565006.
2
Atrial and ventricular pacing after open heart surgery.心脏直视手术后的心房和心室起搏
Thorax. 1973 Jan;28(1):9-14. doi: 10.1136/thx.28.1.9.
3
Beta-adrenergic receptor blocking drugs in angina pectoris.β-肾上腺素能受体阻滞剂在心绞痛中的应用。
Drugs. 1974;7(1):55-84. doi: 10.2165/00003495-197407010-00005.
4
Pharmacodynamic properties of beta-adrenergic receptor blocking drugs in man.β-肾上腺素能受体阻断药在人体中的药效学特性。
Drugs. 1974;7(1):8-38. doi: 10.2165/00003495-197407010-00002.
5
The clinical pharmacology of beta adrenergic blocking drugs.β肾上腺素能阻断药物的临床药理学。
J R Coll Physicians Lond. 1976 Oct;11(1):21-34.
本文引用的文献
1
PROPRANOLOL (INDERAL) IN PERSISTENT VENTRICULAR FIBRILLATION.普萘洛尔（心得安）用于持续性室颤
Br Med J. 1965 Apr 3;1(5439):895-6. doi: 10.1136/bmj.1.5439.895.
2
Long-term prevention of paroxysmal arrhythmias with propranolol therapy.普萘洛尔治疗对阵发性心律失常的长期预防作用。
Am J Med Sci. 1967 Sep;254(3):257-65.
3
Effects of propranolol and its stereoisomers upon coronary vascular resistance.
Circ Res. 1967 Sep;21(3):305-17. doi: 10.1161/01.res.21.3.305.
4
Haemodynamic effects of propranolol (Inderal) in acute myocardial infarction.普萘洛尔（心得安）在急性心肌梗死中的血流动力学效应。
Br Med J. 1967 Jan 21;1(5533):141-3. doi: 10.1136/bmj.1.5533.141.
5
Optical isomers of propranolol.普萘洛尔的光学异构体。
Nature. 1966 Jun 25;210(5043):1336-8. doi: 10.1038/2101336a0.
6
The haemodynamic effects of atropine combined with propranolol in acute myocardial infarction.阿托品联合普萘洛尔在急性心肌梗死中的血流动力学效应。
Med J Aust. 1968 Mar 2;1(9):333-4. doi: 10.5694/j.1326-5377.1968.tb28539.x.
7
Propranolol as an antiarrhythmic agent.普萘洛尔作为一种抗心律失常药物。
Am Heart J. 1967 Aug;74(2):283-5. doi: 10.1016/0002-8703(67)90291-8.
8
The use of beta-adrenergic receptor blocking drugs in dysrhythmias.β-肾上腺素能受体阻断药物在心律失常中的应用。
Prog Cardiovasc Dis. 1969 Jul;12(1):16-39. doi: 10.1016/0033-0620(69)90033-4.
9
Haemodynamic effects of rapid digitalization following acute myocardial infarction.急性心肌梗死后快速洋地黄化的血流动力学效应
Br Heart J. 1968 May;30(3):373-6. doi: 10.1136/hrt.30.3.373.
10
A comparison of the effects of (plus of minus)-propranolol and (plus)-propranolol in anaesthetized dogs; beta-receptor blocking and haemodynamic action.（±）-普萘洛尔与（+）-普萘洛尔对麻醉犬作用的比较；β受体阻断及血流动力学作用
J Pharm Pharmacol. 1969 Apr;21(4):241-7. doi: 10.1111/j.2042-7158.1969.tb08239.x.
Zotero 插件