Cummings R, Lykke A W
Br J Exp Pathol. 1970 Feb;51(1):19-27.
The vascular exudative response to cutaneous crush injury was studied in the rat by estimating the leakage of circulating Evans' blue as well as by labelling abnormally permeable vessels with circulating colloidal carbon. The time-course of increased vascular permeability evoked by moderate crush injury is characterized by a monophasic response which has a rapid onset and lasts no more than 4 hr. Increments in the intensity and/or duration of the stimulus are matched by increased intensity and duration of the monophasic response, but with strong crushing the initial phase is followed by a second or delayed response occurring 3-6 hr after injury. Labelling with circulating colloidal carbon indicates that in both phases of the permeability response, the effects are confined to venules. Antagonists of histamine and serotonin partially suppress exudation in the initial ½ hr after injury, whereas antagonists of kinins and serotonin partially suppress the delayed phase of exudation.
通过评估循环伊文思蓝的渗漏以及用循环胶体碳标记异常通透的血管，对大鼠皮肤挤压伤后的血管渗出反应进行了研究。中度挤压伤引起的血管通透性增加的时间进程以单相反应为特征，该反应起病迅速，持续时间不超过4小时。刺激强度和/或持续时间的增加与单相反应强度和持续时间的增加相匹配，但在强力挤压时，初始阶段之后会出现第二个或延迟反应，发生在损伤后3 - 6小时。用循环胶体碳标记表明，在通透性反应的两个阶段，作用均局限于小静脉。组胺和5 -羟色胺拮抗剂在损伤后的最初半小时内部分抑制渗出，而激肽和5 -羟色胺拮抗剂部分抑制渗出的延迟阶段。
