Phair J P, Eisenfeld A J, Levine R J, Kantor F S
Immunology. 1970 May;18(5):611-9.
Administration of a specific histidine decarboxylase inhibitor, 4-bromo-3-hydroxybenzyloxyamine (brocresine) failed to affect PCA or delayed hypersensitivity reactions in guinea-pigs. Skin histamine levels measured following PCA reactions, when the skin was refractory to a second stimulus showed no significant changes in both treated and untreated animals. Triprolidine, an antihistamine, also failed to significantly alter PCA reactivity. These findings may be interpreted to mean that the operative pool of histamine is very small, its production unaffected by brocresine and its action protected from the effects of antihistamines. Alternatively, it seems more likely that histamine plays little role in the PCA reactions of guinea-pigs.
给予一种特定的组氨酸脱羧酶抑制剂4-溴-3-羟基苄氧胺（布罗克辛）未能影响豚鼠的被动皮肤过敏反应（PCA）或迟发型超敏反应。在PCA反应后测量皮肤组胺水平，此时皮肤对第二次刺激不敏感，结果显示，无论是治疗组还是未治疗组动物，组胺水平均无显著变化。抗组胺药曲普利啶也未能显著改变PCA反应性。这些发现可以解释为，组胺的作用池非常小，其产生不受布罗克辛的影响，其作用也不受抗组胺药的影响。或者，组胺在豚鼠PCA反应中可能起的作用很小，这种可能性似乎更大。
