Squires J W, Pinch L W
JAMA. 1979 Jun 1;241(22):2417-8.
A 27-year-old woman received heparin sodium for 152 days because of antepartum iliofemoral thrombophlebitis. At the end of this time, spinal osteoporosis and multiple vertebral fractures became clinically evident and were attributed to the prolonged administration of heparin. Previously reported cases of "heparin osteoporosis" were reviewed. The significance of the daily dose of heparin and the duration of therapy are reemphasized. This therapeutic complication and the management of antepartum iliofemoral thrombophlebitis are discussed. Prolonged administration of heparin in daily doses exceeding 10,000 units is potentially hazardous.
一名27岁女性因产前髂股静脉血栓性静脉炎接受肝素钠治疗152天。在此期间结束时，脊柱骨质疏松症和多发性椎体骨折在临床上变得明显，这归因于肝素的长期使用。回顾了先前报道的“肝素性骨质疏松症”病例。再次强调了肝素每日剂量和治疗持续时间的重要性。讨论了这种治疗并发症以及产前髂股静脉血栓性静脉炎的处理。每日剂量超过10000单位的肝素长期使用具有潜在危险性。
