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CS - 1170在儿童中的临床研究(作者译)

[Clinical study of CS-1170 in children (author's transl)].

作者信息

Nagamatsu K, Hamada I

出版信息

Jpn J Antibiot. 1979 Feb;32(2):238-40.

PMID:439395
Abstract

CS-1170 was administered to 9 cases of the pediatric field. The clinical effect was good in 6 cases, fair in 2, and poor in one. The doses ranged from 80 mg/kg to 100 mg/kg, and an intravenous injection of 300 mg/kg was given in only one case. In the poor case, continuous instillation of 100 mg/kg was given. In the 2 fair cases, the patients with septicemia received 80 mg/kg and 300 mg/kg, respectively. There was no improvement in clinical findings, but the bacteria alone disappeared. As side effects, vasalgia due to intravenous injection was observed in 2 cases, but it disappared by the intravenous injection of 500 mg dissolved in 10 ml. No case showed eruption, diarrhea, or acidophilia. GOT or GPT increased in no case either.

摘要

CS - 1170应用于9例儿科病例。6例临床效果良好,2例尚可,1例较差。剂量范围为80毫克/千克至100毫克/千克,仅1例进行了300毫克/千克的静脉注射。效果较差的那例进行了100毫克/千克的持续滴注。在2例效果尚可的病例中,败血症患者分别接受了80毫克/千克和300毫克/千克的剂量。临床症状无改善,但仅细菌消失。作为副作用,2例出现静脉注射引起的血管疼痛,但通过静脉注射溶解于10毫升中的500毫克后消失。无一例出现皮疹、腹泻或嗜酸粒细胞增多。也无一例谷草转氨酶(GOT)或谷丙转氨酶(GPT)升高。

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