Nagamatsu K, Hamada I
Jpn J Antibiot. 1979 Feb;32(2):238-40.
CS-1170 was administered to 9 cases of the pediatric field. The clinical effect was good in 6 cases, fair in 2, and poor in one. The doses ranged from 80 mg/kg to 100 mg/kg, and an intravenous injection of 300 mg/kg was given in only one case. In the poor case, continuous instillation of 100 mg/kg was given. In the 2 fair cases, the patients with septicemia received 80 mg/kg and 300 mg/kg, respectively. There was no improvement in clinical findings, but the bacteria alone disappeared. As side effects, vasalgia due to intravenous injection was observed in 2 cases, but it disappared by the intravenous injection of 500 mg dissolved in 10 ml. No case showed eruption, diarrhea, or acidophilia. GOT or GPT increased in no case either.
CS - 1170应用于9例儿科病例。6例临床效果良好,2例尚可,1例较差。剂量范围为80毫克/千克至100毫克/千克,仅1例进行了300毫克/千克的静脉注射。效果较差的那例进行了100毫克/千克的持续滴注。在2例效果尚可的病例中,败血症患者分别接受了80毫克/千克和300毫克/千克的剂量。临床症状无改善,但仅细菌消失。作为副作用,2例出现静脉注射引起的血管疼痛,但通过静脉注射溶解于10毫升中的500毫克后消失。无一例出现皮疹、腹泻或嗜酸粒细胞增多。也无一例谷草转氨酶(GOT)或谷丙转氨酶(GPT)升高。