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Sterol metabolism. 8. Conversion of cholesterol 20 alpha-hydroperoxide to 20 alpha, 21- and 20 alpha, 22R-dihydroxycholesterol by adrenal cortex mitochondria.

作者信息

Van Lier J E, Smith L L

出版信息

Biochim Biophys Acta. 1970 Jun 9;210(1):153-63. doi: 10.1016/0005-2760(70)90070-6.

DOI:10.1016/0005-2760(70)90070-6
PMID:4393955
Abstract
摘要

相似文献

1
Sterol metabolism. 8. Conversion of cholesterol 20 alpha-hydroperoxide to 20 alpha, 21- and 20 alpha, 22R-dihydroxycholesterol by adrenal cortex mitochondria.
Biochim Biophys Acta. 1970 Jun 9;210(1):153-63. doi: 10.1016/0005-2760(70)90070-6.
2
Sterol metabolism. XVI. Cholesterol 20-alpha-hydroperoxide as an intermediate in pregnenolone biosynthesis from cholesterol.
Biochem Biophys Res Commun. 1970 Aug 11;40(3):510-6. doi: 10.1016/0006-291x(70)90931-9.
3
Exclusion of 20(22)-dehydrocholesterol as an intermediate in the biosynthesis of pregnenolone in bovine adrenocortical mitochondrial acetone-dried powder preparations.
Steroids. 1976 May;27(5):691-701. doi: 10.1016/s0039-128x(76)90224-5.
4
Mass spectrometric study of the enzymatic conversion of cholesterol to (22R)-22-hydroxycholesterol, (20R,22R)-20,22-dihydroxycholesterol, and pregnenolone, and of (22R)-22-hydroxycholesterol to the lgycol and pregnenolone in bovine adrenocortical preparations. Mode of oxygen incorporation.牛肾上腺皮质制剂中胆固醇向（22R）-22-羟胆固醇、（20R，22R）-20，22-二羟胆固醇和孕烯醇酮的酶促转化，以及（22R）-22-羟胆固醇向二醇和孕烯醇酮的质谱研究。氧掺入模式。
J Biol Chem. 1975 Dec 10;250(23):9028-37.
5
Cofactor requirements for the conversion of cholesterol sulfate to pregnenolone sulfate by a submitochondrial system from bovine adrenal ortex.牛肾上腺皮质亚线粒体系统将硫酸胆固醇转化为硫酸孕烯醇酮所需的辅助因子。
Biochem Biophys Res Commun. 1968 Jun 28;31(6):925-31. doi: 10.1016/0006-291x(68)90541-x.
6
Substrate-induced difference spectra and cholesterol to pregnenolone conversion with adrenal heme protein P-450.
Biochemistry. 1972 Feb 15;11(4):573-7. doi: 10.1021/bi00754a015.
7
Transformation of labeled cholesterol, 20-alpha-hydroxycholesterol, (22R)-22-hydroxycholesterol, and (22R)-20-alpha, 22-dihydroxycholesterol by adrenal acetone-dried preparations from guinea pigs, cattle and man.豚鼠、牛和人的肾上腺丙酮干燥制剂对标记胆固醇、20-α-羟基胆固醇、(22R)-22-羟基胆固醇和(22R)-20-α,22-二羟基胆固醇的转化作用
Steroids. 1970 Jan;15(1):13-60. doi: 10.1016/s0039-128x(70)80003-4.
8
Inhibition of the conversion of cholesterol to pregnenolone in bovine adrenocortical preparations.在牛肾上腺皮质制剂中抑制胆固醇向孕烯醇酮的转化。
Steroids. 1976 Mar;27(3):361-82. doi: 10.1016/0039-128x(76)90057-x.
9
Pregnenolone formation from cholesterol in bovine adrenal cortex mitochondria: proposal of a new mechanism.
FEBS Lett. 1975 Feb 1;50(2):204-9. doi: 10.1016/0014-5793(75)80489-3.
10
Steroid hydroperoxides as intermediates in steroid biogenesis.甾体氢过氧化物作为甾体生物合成的中间体。
Biochem J. 1971 Nov;125(2):47P. doi: 10.1042/bj1250047p.

引用本文的文献

1
Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1.同位素标记研究支持亲电化合物 I 铁活性物种 FeO(3+) 用于胆固醇侧链裂解酶细胞色素 P450 11A1 的碳-碳键断裂反应。
J Am Chem Soc. 2016 Sep 21;138(37):12124-41. doi: 10.1021/jacs.6b04437. Epub 2016 Sep 12.
2
Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols.胆固醇氢过氧化物作为胆固醇代谢细胞色素P450酶的底物以及25-羟基胆固醇和其他氧化甾醇的替代来源。
Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11138-42. doi: 10.1002/anie.201505002. Epub 2015 Jul 29.
3
Steroid hydroperoxides as intermediates in steroid biogenesis.甾体氢过氧化物作为甾体生物合成的中间体。
Biochem J. 1971 Nov;125(2):47P. doi: 10.1042/bj1250047p.
4
Cytochrome P-450 as a microsomal peroxidase in steroid hydroxylations.细胞色素P - 450作为甾体羟化中的微粒体过氧化物酶。
Biochem J. 1971 Nov;125(2):12P. doi: 10.1042/bj1250012pa.