Freundlieb C, Höck A, Vyska K, Smolarz A, Feinendegen L E
Nuklearmedizin. 1979;18(6):274-7.
The effects of single equipotent doses of Propranolol and Carazolol on cardiac haemodynamics of normal persons were investigated in a placebo-controlled double-blind study by radiocardiographic measurements of minimal cardiac transit times (MTTs). 90 min after oral application of 40 mg Propranolol a significant (p less than 0.005) prolongation of MTTs between the right auricle and the aortic root by 25% could be observed. A corresponding effect after treatment with 5 mg Carazolol was not recognizable (p greater than 0.05). Both substances strongly reduced the heart rate. The negative chronotropic effects of both beta-blockers were indistinguishable (p greater than 0.05).
在一项安慰剂对照的双盲研究中，通过放射心动图测量最小心脏通过时间（MTTs），研究了单剂量等效的普萘洛尔和卡唑洛尔对正常人心脏血流动力学的影响。口服40 mg普萘洛尔90分钟后，可观察到右心房与主动脉根部之间的MTTs显著延长（p < 0.005），延长了25%。服用5 mg卡唑洛尔后未观察到相应效果（p > 0.05）。两种药物均显著降低心率。两种β受体阻滞剂的负性变时作用无明显差异（p > 0.05）。
