家蝇中一种依赖NADPH的硝基还原酶的活性。

Activity of an NADPH-dependent nitroreductase in houseflies.

作者信息

Lichtenstein E P, Fuhremann T W

出版信息

Science. 1971 May 7;172(3983):589-91. doi: 10.1126/science.172.3983.589.

DOI:10.1126/science.172.3983.589

Abstract

A nitroreductase, reducing parathion to aminoparathion, was found in the soluble fraction that was obtained from abdomens of female houseflies. The reaction required reduced nicotinamide adenine dinucleotide phosphate (NADPH), but was not affected by the presence or absence of oxygen. Further degradation of aminoparathion into water-soluble compounds occurred in NADPH-fortified incubation mixtures over prolonged incubation periods. The effect of sesamex or SKF 525-A on these reactions is described.

摘要

在从雌性家蝇腹部获得的可溶性部分中发现了一种将对硫磷还原为氨基对硫磷的硝基还原酶。该反应需要还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH），但不受氧气存在与否的影响。在延长的孵育期内，在添加了NADPH的孵育混合物中，氨基对硫磷进一步降解为水溶性化合物。描述了芝麻素或SKF 525 - A对这些反应的影响。