百里胺对左旋多巴和多巴胺所致散瞳的作用。
Action of thymoxamine on mydriasis induced by levodopa and dopamine.
作者信息
Spiers A S, Calne D B, Vakil S D, French T M
出版信息
Br Med J. 1971 May 22;2(5759):438-9. doi: 10.1136/bmj.2.5759.438.
Abstract
Eye-drops of levodopa and dopamine induce pupillary dilatation which is inhibited by thymoxamine, an alpha-adrenergic blocking drug. This indicates that the mydriatic action of levodopa and dopamine involves excitation of alpha-adrenergic receptors of the dilator pupillae muscle. Such a conclusion is in accord with the previously expressed suggestion that levodopa is rapidly converted to dopamine, which displaces noradrenaline from adrenergic nerve endings.The findings that dopamine exerts alpha-adrenergic effects at the periphery may be construed as evidence in support of the view that the hypotensive action of levodopa is mediated via the central nervous system.
摘要
左旋多巴和多巴胺眼药水可引起瞳孔扩张，而α-肾上腺素能阻断药噻吗洛尔可抑制这种扩张。这表明左旋多巴和多巴胺的散瞳作用涉及瞳孔开大肌α-肾上腺素能受体的兴奋。这一结论与之前提出的观点一致，即左旋多巴迅速转化为多巴胺，后者从肾上腺素能神经末梢取代去甲肾上腺素。多巴胺在外周发挥α-肾上腺素能作用的发现可被视为支持左旋多巴降压作用是通过中枢神经系统介导这一观点的证据。
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