Calne D B, Brennan J, Spiers A S, Stern G M
Br Med J. 1970 Feb 21;1(5694):474-5. doi: 10.1136/bmj.1.5694.474.
In 20 patients with idiopathic Parkinsonism maximum tolerated doses of L-dopa were found to induce a mean reduction in blood pressure (erect systolic) of 19.3 mm.Hg, without any significant change in pulse rate. This hypotension may be due to dopamine, acting on adrenergic nerve endings or on the central nervous system itself.
在20例特发性帕金森病患者中,发现左旋多巴的最大耐受剂量可使平均血压(直立位收缩压)降低19.3毫米汞柱,而脉率无显著变化。这种低血压可能是由于多巴胺作用于肾上腺素能神经末梢或中枢神经系统本身所致。