酪胺对人脐动脉的体外作用。
Effect of tyramine on human umbilical artery in vitro.
作者信息
Gulati O D, Kelkar V V
出版信息
Br J Pharmacol. 1971 May;42(1):155-8. doi: 10.1111/j.1476-5381.1971.tb07096.x.
Abstract
Fifteen of twenty-one perfused human umbilical artery preparations constricted in response to tyramine. These responses were unaffected by atropine, mepyramine or bromolysergic acid diethylamide but were blocked by phentolamine or dihydroergotamine. Cocaine augmented the constriction responses to tyramine or noradrenaline but not those to adrenaline, acetylcholine or 5-hydroxytryptamine. Infusion of noradrenaline restored the responses of preparations which had become tachyphylactic to tyramine.
摘要
21个灌注的人脐动脉制剂中有15个对酪胺产生收缩反应。这些反应不受阿托品、美吡拉敏或溴麦角酰二乙胺的影响，但被酚妥拉明或双氢麦角胺阻断。可卡因增强了对酪胺或去甲肾上腺素的收缩反应，但对肾上腺素、乙酰胆碱或5-羟色胺的反应没有增强。输注去甲肾上腺素恢复了对酪胺产生快速耐受性的制剂的反应。
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