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异丙肾上腺素和氨茶碱对豚鼠离体心脏变时性反应及迷走神经刺激和乙酰胆碱的影响。

Effects of isoprenaline and aminophylline on the chronotropic responses of the isolated guineapig heart to vagal stimulation and acetylcholine.

作者信息

Hadhazy P

出版信息

Br J Pharmacol. 1971 Jul;42(3):364-70. doi: 10.1111/j.1476-5381.1971.tb07120.x.

DOI:10.1111/j.1476-5381.1971.tb07120.x
PMID:4397803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665667/
Abstract
  1. In isolated perfused guinea-pig hearts, isoprenaline (2 x 10(-8) g/ml) reduced the negative chronotropic responses to vagal stimulation and to exogenous acetylcholine.2. The beta-adrenoceptor antagonist LB46 (2 x 10(-8) g/ml) abolished the effect of isoprenaline in reducing vagal bradycardia. LB46 itself did not alter the responses to vagal stimulation.3. Increase in (86)Rb efflux induced by acetylcholine was not affected by isoprenaline.4. Aminophylline (2.3 x 10(-4) g/ml) almost abolished the negative chronotropic effect of vagal stimulation.5. The ;antivagal' effects of isoprenaline and aminophylline may be at a common site beyond the level of the cardiac beta-adrenoceptors, perhaps related to cyclic-3',5'-AMP and/or sodium transport.
摘要

  1. 在离体灌注豚鼠心脏中，异丙肾上腺素（2×10⁻⁸克/毫升）可降低对迷走神经刺激和外源性乙酰胆碱的负性变时反应。

  2. β-肾上腺素能受体拮抗剂LB46（2×10⁻⁸克/毫升）消除了异丙肾上腺素减轻迷走性心动过缓的作用。LB46本身并未改变对迷走神经刺激的反应。

  3. 乙酰胆碱诱导的（⁸⁶）Rb外流增加不受异丙肾上腺素影响。

  4. 氨茶碱（2.3×10⁻⁴克/毫升）几乎消除了迷走神经刺激的负性变时作用。

  5. 异丙肾上腺素和氨茶碱的“抗迷走”作用可能在心脏β-肾上腺素能受体水平以上的共同部位，可能与环-3',5'-AMP和/或钠转运有关。

相似文献

1
Effects of isoprenaline and aminophylline on the chronotropic responses of the isolated guineapig heart to vagal stimulation and acetylcholine.异丙肾上腺素和氨茶碱对豚鼠离体心脏变时性反应及迷走神经刺激和乙酰胆碱的影响。
Br J Pharmacol. 1971 Jul;42(3):364-70. doi: 10.1111/j.1476-5381.1971.tb07120.x.
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Effect of acetylcholine on changes in contractility, heart rate and phosphorylase activity produced by isoprenaline, salbutamol and amino-phylline in the perfused guinea-pig heart.乙酰胆碱对异丙肾上腺素、沙丁胺醇和氨茶碱在豚鼠离体心脏灌流中所引起的心肌收缩力、心率及磷酸化酶活性变化的影响。
Br J Pharmacol. 1975 Apr;53(4):531-8. doi: 10.1111/j.1476-5381.1975.tb07391.x.
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Pharmacology. 1973;9(5):285-93. doi: 10.1159/000136398.
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本文引用的文献

1
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver.腺苷酸环化酶。III. 儿茶酚胺和胆碱酯对心肌和肝脏制剂生成3',5'-磷酸腺苷的影响。
J Biol Chem. 1962 Apr;237:1233-8.
2
Mechanism of the positive chronotropic response to nicotine.尼古丁正性变时反应的机制。
J Pharmacol Exp Ther. 1962 Aug;137:206-12.
3
EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION.
Jpn J Pharmacol. 1964 Jun;14:118-37. doi: 10.1254/jjp.14.118.
4
LOCAL CHOLINERGIC-ADRENERGIC INTERACTION: MECHANISM FOR THE BIPHASIC CHRONOTROPIC RESPONSE TO NERVE STIMULATION.局部胆碱能 - 肾上腺素能相互作用：对神经刺激产生双相变时反应的机制
J Pharmacol Exp Ther. 1963 Oct;142:31-8.
5
Generation and conduction of impulses in the heart as affected by drugs.药物对心脏冲动的产生和传导的影响。
Pharmacol Rev. 1963 Jun;15:277-332.
6
Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
J Biol Chem. 1962 Apr;237:1244-50.
7
Restoration of chronotropic effects of vagus stimulation on isolated perfused heart of the guinea pig.迷走神经刺激对豚鼠离体灌注心脏变时效应的恢复。
Am J Physiol. 1956 Aug;186(2):313-6. doi: 10.1152/ajplegacy.1956.186.2.313.
8
The effect on the isolated rabbit heart of vagal stimulation and its modification by cocaine, hexamethonium and ouabain.迷走神经刺激对离体兔心脏的影响以及可卡因、六甲铵和哇巴因对其的影响。
J Physiol. 1956 Mar 28;131(3):678-89. doi: 10.1113/jphysiol.1956.sp005493.
9
Interactions of K, Na, and vagal stimulation in the S-A node of the rabbit.钾、钠与迷走神经刺激在兔窦房结中的相互作用。
Am J Physiol. 1967 Feb;212(2):416-23. doi: 10.1152/ajplegacy.1967.212.2.416.
10
Effect of combined sympathetic and vagal stimulation on heart rate in the dog.交感神经与迷走神经联合刺激对犬心率的影响。
Circ Res. 1969 Apr;24(4):567-73. doi: 10.1161/01.res.24.4.567.