异丙肾上腺素和氨茶碱对豚鼠离体心脏变时性反应及迷走神经刺激和乙酰胆碱的影响。
Effects of isoprenaline and aminophylline on the chronotropic responses of the isolated guineapig heart to vagal stimulation and acetylcholine.
作者信息
Hadhazy P
出版信息
Br J Pharmacol. 1971 Jul;42(3):364-70. doi: 10.1111/j.1476-5381.1971.tb07120.x.
Abstract
- In isolated perfused guinea-pig hearts, isoprenaline (2 x 10(-8) g/ml) reduced the negative chronotropic responses to vagal stimulation and to exogenous acetylcholine.2. The beta-adrenoceptor antagonist LB46 (2 x 10(-8) g/ml) abolished the effect of isoprenaline in reducing vagal bradycardia. LB46 itself did not alter the responses to vagal stimulation.3. Increase in (86)Rb efflux induced by acetylcholine was not affected by isoprenaline.4. Aminophylline (2.3 x 10(-4) g/ml) almost abolished the negative chronotropic effect of vagal stimulation.5. The ;antivagal' effects of isoprenaline and aminophylline may be at a common site beyond the level of the cardiac beta-adrenoceptors, perhaps related to cyclic-3',5'-AMP and/or sodium transport.
摘要
在离体灌注豚鼠心脏中，异丙肾上腺素（2×10⁻⁸克/毫升）可降低对迷走神经刺激和外源性乙酰胆碱的负性变时反应。
β-肾上腺素能受体拮抗剂LB46（2×10⁻⁸克/毫升）消除了异丙肾上腺素减轻迷走性心动过缓的作用。LB46本身并未改变对迷走神经刺激的反应。
乙酰胆碱诱导的（⁸⁶）Rb外流增加不受异丙肾上腺素影响。
氨茶碱（2.3×10⁻⁴克/毫升）几乎消除了迷走神经刺激的负性变时作用。
异丙肾上腺素和氨茶碱的“抗迷走”作用可能在心脏β-肾上腺素能受体水平以上的共同部位，可能与环-3',5'-AMP和/或钠转运有关。
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