Pien F D, Michael N L, Mamiya R, Takaki H, Slavish S, Bruce A, Moreno-Cabral R J
J Thorac Cardiovasc Surg. 1979 Jun;77(6):908-13.
A randomized, prospective study of the relative effectiveness of clindamycin versus cephalothin was performed in 263 adult patients having cardiac surgery from September, 1977, to August, 1978. There were no statistically significant differences in frequency of postoperative infections in these two antibiotic groups. Wound infection developed in 6.5 percent of the cephalothin group and 3.2 percent of the clindamycin group. Urinary tract infection developed in 5.6 percent of the clindamycin group and 2.1 percent of the cephalothin group. Four bacteremic episodes occurred in the clindamycin-treated patients, and one episode of bacteremia occurred in a cephalothin-treated patient. No cases of endocarditis occurred during the study. Clindamycin deserved consideration as an alternative prophylactic agent to cephalothin for cardiac surgery.
1977年9月至1978年8月期间，对263例接受心脏手术的成年患者进行了一项关于克林霉素与头孢噻吩相对有效性的随机前瞻性研究。这两个抗生素组术后感染频率无统计学显著差异。头孢噻吩组伤口感染发生率为6.5%，克林霉素组为3.2%。克林霉素组尿路感染发生率为5.6%，头孢噻吩组为2.1%。接受克林霉素治疗的患者发生了4次菌血症，接受头孢噻吩治疗的患者发生了1次菌血症。研究期间未发生心内膜炎病例。克林霉素值得作为心脏手术中头孢噻吩的替代预防药物加以考虑。
