Ammon H V, Thomas P J, Phillipis S F
Lipids. 1979 Apr;14(4):395-400. doi: 10.1007/BF02533424.
The effect of lecithin on jejunal absorption of fatty acids and octadecenoylglycerol was studied in healthy volunteers with a jejunal perfusion system which excluded pancreatic and biliary secretions from the test segment. Lecithin significantly reduced the absorption of oleic acid (P less than 0.05) and octadecenoylglycerol (P less than 0.01), while it had no effect on the absorption of ricinoleic acid. In vitro, lecithin reduced monomer activities of all three lipids; the changes were greater for oleic acid and octadecenoylglycerol than for ricinoleic acid (P less than 0.02). From these data it is concluded that lecithin reduces monomer activity of fatty acids in mixed micellar solutions and that it can thereby reduce the absorption rates of micellar lipids. Intact lecithin is not absorbed under these conditions. Maldigestion of lecithin in pancreatic insufficiency may, therefore, aggravate the steatorrhea observed in this condition.
利用空肠灌注系统在健康志愿者中研究了卵磷脂对空肠脂肪酸和十八碳烯酰甘油吸收的影响，该系统可将胰腺和胆汁分泌排除在测试段之外。卵磷脂显著降低了油酸（P<0.05）和十八碳烯酰甘油（P<0.01）的吸收，而对蓖麻油酸的吸收没有影响。在体外，卵磷脂降低了所有三种脂质的单体活性；油酸和十八碳烯酰甘油的变化大于蓖麻油酸（P<0.02）。从这些数据可以得出结论，卵磷脂降低了混合胶束溶液中脂肪酸的单体活性，从而可以降低胶束脂质的吸收速率。在这些条件下，完整的卵磷脂不被吸收。因此，胰腺功能不全时卵磷脂消化不良可能会加重这种情况下观察到的脂肪泻。
