金属离子在猪心三磷酸吡啶核苷酸依赖性异柠檬酸脱氢酶催化反应中的作用。II. 对氨基酸残基催化特性和反应性的影响 - Suppr

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Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues.

作者信息

Colman R F

出版信息

J Biol Chem. 1972 Jan 10;247(1):215-23.

PMID:4401583

Abstract

摘要

相似文献

Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues.金属离子在猪心三磷酸吡啶核苷酸依赖性异柠檬酸脱氢酶催化反应中的作用。II. 对氨基酸残基催化特性和反应性的影响

J Biol Chem. 1972 Jan 10;247(1):215-23.

Influence of substrates and coenzymes on the role of manganous ion in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase.底物和辅酶对猪心三磷酸吡啶核苷酸依赖性异柠檬酸脱氢酶催化反应中锰离子作用的影响。

Biochemistry. 1976 Sep 7;15(18):4034-41. doi: 10.1021/bi00663a018.

The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. II. Dead-end and multiple inhibition studies.猪心脏三磷酸吡啶核苷酸-异柠檬酸脱氢酶的动力学。II. 终产物抑制和多重抑制研究。

J Biol Chem. 1974 May 10;249(9):2928-31.

A glutamyl residue in the active site of triphosphopyridine nucleotide-dependent isocitrate dehydrogenase of pig heart.

J Biol Chem. 1973 Dec 10;248(23):8137-43.

Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. I. Magnetic resonance and binding studies of the complexes of enzyme, manganous ion, and substrates.金属离子在猪心三磷酸吡啶核苷酸依赖性异柠檬酸脱氢酶催化反应中的作用。I. 酶、锰离子和底物复合物的磁共振及结合研究。

J Biol Chem. 1972 Jan 10;247(1):209-14.

1H nuclear magnetic resonance studies of the conformation and environment of nucleotides bound to pig heart NADP+-dependent isocitrate dehydrogenase.对与猪心NADP⁺依赖性异柠檬酸脱氢酶结合的核苷酸的构象和环境进行的¹H核磁共振研究。

Biochemistry. 1985 Sep 24;24(20):5378-87. doi: 10.1021/bi00341a016.

The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. II. Effect of N-ethylmaleimide on kinetic properties.巯基在异柠檬酸脱氢酶催化功能中的作用。II. N-乙基马来酰亚胺对动力学性质的影响。

J Biol Chem. 1970 Feb 10;245(3):601-7.

The kinetics of pig heart triphosphopyridine nucleotide-isocitrate dehydrogenase. I. Initial velocity, substrate and product inhibition, and isotope exchange studies.猪心脏三磷酸吡啶核苷酸异柠檬酸脱氢酶的动力学。I. 初速度、底物和产物抑制以及同位素交换研究。

J Biol Chem. 1974 May 10;249(9):2920-7.

Nicotinamide adenine dinucleotide phosphate linked isocitrate dehydrogenase. Catalytic activation by the reduced coenzyme product of the reaction.烟酰胺腺嘌呤二核苷酸磷酸连接的异柠檬酸脱氢酶。反应的还原型辅酶产物对其催化激活作用。

Biochemistry. 1976 Apr 20;15(8):1761-6. doi: 10.1021/bi00653a026.

Isotope effect studies of the role of metal ions in isocitrate dehydrogenase.金属离子在异柠檬酸脱氢酶中作用的同位素效应研究

Biochemistry. 1977 Mar 22;16(6):1129-35. doi: 10.1021/bi00625a016.

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An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.一个酸性残基埋藏在异柠檬酸脱氢酶 1（IDH1）的二聚体界面中，有助于调节催化和 pH 敏感性。

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NADP-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione.谷胱甘肽的适度螯合作用使得依赖 NADP 的胞质异柠檬酸脱氢酶在镉存在的情况下提供 NADPH。

J Biol Inorg Chem. 2018 Aug;23(6):849-860. doi: 10.1007/s00775-018-1581-5. Epub 2018 Jun 19.

An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation.一种超氧化物歧化酶模拟物可保护依赖烟酰胺腺嘌呤二核苷酸磷酸（NADP+）的异柠檬酸脱氢酶免受氧化失活。

Free Radic Res. 2008 Jul;42(7):618-24. doi: 10.1080/10715760802209639.

Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase.Ser95、Asn97和Thr78对猪源NADP依赖型异柠檬酸脱氢酶的催化功能很重要。

Protein Sci. 2005 Jan;14(1):140-7. doi: 10.1110/ps.041091805. Epub 2004 Dec 2.

NADP-specific isocitrate dehydrogenase from the citric acid-accumulating fungus Aspergillus niger.来自柠檬酸积累真菌黑曲霉的NADP特异性异柠檬酸脱氢酶。

Biochem J. 1986 Jun 1;236(2):549-57. doi: 10.1042/bj2360549.

Absence of direct coenzyme transfer in an A-B dehydrogenase system.A-B脱氢酶系统中缺乏直接辅酶转移。

Biochem J. 1987 Nov 15;248(1):269-71. doi: 10.1042/bj2480269.

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