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[二乙戊酰胺重度中毒的首次经验(作者译)]

[First experiences in severe intoxications with diaethylpentenamide (author's transl)].

作者信息

Wöltje M, Havighorst E, Wellhöner H H

出版信息

Med Klin. 1979 Apr 13;74(15):570-2.

PMID:440182
Abstract

14 patients suffering from diaethylpentenamide-intoxication were treated in the medical School Hannover, in the period from January 1 to June 6, 1978. 7 of the patients had to be treated in the intensive care unit, and of these 5 received haemoperfusion therapy. The indications for haemoperfusion were severe clinical symptoms and a plasma diaethylpentenamide-level in excess 285 mu mol/l. The duration of coma was significantly less for patients treated by haemoperfusions than for those without haemoperfusion. Although preparations containing diaethylpentenamide are only available through prescription in Germany now, it can be expected that these drugs will continue to be used in cases of suicidal intent. Haemoperfusion seems to be the most effective therapy of diaethylpentenamide-intoxication.

摘要

1978年1月1日至6月6日期间,汉诺威医学院对14名因二乙戊酰氨中毒的患者进行了治疗。其中7名患者需在重症监护病房接受治疗,这7名患者中有5名接受了血液灌流治疗。血液灌流的指征为严重的临床症状以及血浆中二乙戊酰氨水平超过285微摩尔/升。接受血液灌流治疗的患者昏迷持续时间明显短于未接受血液灌流治疗的患者。尽管目前在德国含有二乙戊酰氨的制剂只能凭处方获得,但可以预计这些药物在有自杀意图的情况下仍会继续被使用。血液灌流似乎是治疗二乙戊酰氨中毒最有效的疗法。

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