在特定白细胞表面可检测到组胺受体。
Receptors for histamine can be detected on the surface of selected leukocytes.
作者信息
Melmon K L, Bourne H R, Weinstein J, Sela M
出版信息
Science. 1972 Aug 25;177(4050):707-9. doi: 10.1126/science.177.4050.707.
PMID:4403369
Abstract
Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histaminie, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.
摘要
通过蛋白质或多肽载体以化学键合方式固定在琼脂糖珠上的组胺无法穿透细胞。即便如此，由此产生的组胺包被的琼脂糖仍能选择性地结合白细胞。尽管组胺分子量较低，但这种结合是通过预先形成的细胞膜受体进行的，并且可以被抗组胺药特异性地竞争性阻断或逆转。
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