红细胞对3,4-二羟基苯丙氨酸（多巴）的脱羧作用：一种由高铁血红蛋白和其他高铁血红素蛋白促进的反应。
Decarboxylation of 3,4-dihydroxyphenylalanine (DOPA) by erythrocytes: a reaction promoted by methemoglobin and other ferriheme proteins.
作者信息
Tate S S, Orlando J, Meister A
出版信息
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2505-8. doi: 10.1073/pnas.69.9.2505.
The decarboxylation of DOPA by erythrocyte hemolysates differs from DOPA decarboxylation catalyzed by aromatic aminoacid decarboxylases that contain vitamin B(6) in several significant respects. The ability of erythrocyte hemolysates to decarboxylate DOPA is associated with interaction between DOPA and methemoglobin; the ferriheme protein is reduced and DOPA is decarboxylated, probably after oxidation to a quinone intermediate. An analogous reaction takes place between DOPA and other ferriheme proteins, such as metmyoglobin and cytochrome c. This phenomenon may be of significance in relation to the side effects observed in patients with Parkinson's disease who are treated with very large doses of DOPA.
红细胞溶血产物对多巴的脱羧作用在几个重要方面不同于由含维生素B6的芳香族氨基酸脱羧酶催化的多巴脱羧作用。红细胞溶血产物使多巴脱羧的能力与多巴和高铁血红蛋白之间的相互作用有关；高铁血红素蛋白被还原，多巴可能在氧化成醌中间体后脱羧。多巴与其他高铁血红素蛋白，如高铁肌红蛋白和细胞色素c之间也会发生类似反应。这种现象可能与帕金森病患者大剂量使用多巴治疗时观察到的副作用有关。
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