Merskey H, Hester R A
Postgrad Med J. 1972 Oct;48(564):594-8. doi: 10.1136/pgmj.48.564.594.
The treatment is described of thirty patients with chronic nervous system lesion causing intractable pain. Moderately good relief of pain was obtained with a combination of phenothiazines (especially pericyazine), antidepressant drugs and antihistamines. The theoretical implications of this are discussed and it is suggested that the drugs in question act partly by virtue of an effect on the multisynaptic neuronal systems whose activities are related to the experience of pain.
本文描述了对30例因慢性神经系统损伤导致顽固性疼痛患者的治疗情况。使用吩噻嗪类药物（尤其是奋乃静）、抗抑郁药和抗组胺药联合治疗，疼痛得到了较好程度的缓解。文中讨论了这一治疗方法的理论意义，并指出相关药物部分是通过作用于多突触神经元系统发挥作用的，这些系统的活动与疼痛体验相关。
