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骨髓来源的淋巴细胞(B细胞):用眼镜蛇因子和新鲜血清进行功能耗竭

Bone marrow-derived lymphoid cells (B cells): functional depletion with cobra factor and fresh serum.

作者信息

Levy N L, Scott D W, Snyderman R

出版信息

Science. 1972 Nov 24;178(4063):866-7. doi: 10.1126/science.178.4063.866.

Abstract

Treatment of rat spleen cells with cobra factor and fresh rat serum provided a simple, rapid means of functionally eliminating complement receptor lymphocytes. Cells able to differentiate into plaque-forming cells in a syngeneic, irradiated host were diminished, but cells able to induce a graft-versus-host reaction were not diminished. There was no effect on plaque-forming cells from an immune spleen.

摘要

用眼镜蛇因子和新鲜大鼠血清处理大鼠脾细胞,提供了一种简单、快速的功能性消除补体受体淋巴细胞的方法。在同基因、经辐射的宿主体内能分化为噬斑形成细胞的细胞数量减少,但能引发移植物抗宿主反应的细胞数量未减少。对来自免疫脾的噬斑形成细胞没有影响。

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