大鼠肝脏将烯丙醇转化为丙烯醛。
Conversion of allyl alcohol into acrolein by rat liver.
作者信息
Serafini-Cessi F
出版信息
Biochem J. 1972 Aug;128(5):1103-7. doi: 10.1042/bj1281103.
Abstract
- Acrolein was detected in rat liver suspensions incubated in the presence of allyl alcohol and allyl formate. Acrolein was determined by condensation of the distilled aldehyde with semicarbazide, followed by spectrophotometric measurement of the semicarbazone at 257nm and identification by paper chromatography. 2. The transformation of allyl alcohol into acrolein occurred in the presence of NAD(+). Inhibitors of rat liver alcohol dehydrogenase inhibited the reaction. 3. It is suggested that the hepatotoxic actions of allyl alcohol and of allyl formate on rat liver are related to their conversion into acrolein.
摘要
- 在烯丙醇和甲酸烯丙酯存在的情况下，在大鼠肝脏悬浮液中检测到了丙烯醛。通过蒸馏醛与氨基脲缩合来测定丙烯醛，随后在257nm处用分光光度法测定氨基脲腙，并通过纸色谱法进行鉴定。2. 在烟酰胺腺嘌呤二核苷酸（NAD(+)）存在的情况下，烯丙醇转化为丙烯醛。大鼠肝脏乙醇脱氢酶的抑制剂抑制了该反应。3. 有人提出，烯丙醇和甲酸烯丙酯对大鼠肝脏的肝毒性作用与其转化为丙烯醛有关。
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