大麻对神经心理的影响。
Neuropsychological effects of marijuana.
作者信息
Klonoff H, Low M, Marcus A
出版信息
Can Med Assoc J. 1973 Jan 20;108(2):150-6 passim.
This study assigned 81 non-naïve subjects, divided into low- and high-dose groups, to four experimental conditions (marijuana/marijuana, marijuana/placebo, placebo/marijuana and placebo/placebo) for two sessions separated by about one week. The low dose was 4.8 mg. Delta(9)-THC followed by 2.4 mg. one hour later. The high dose was 9.1 mg. followed by 4.5 mg. one hour later. A battery of neuropsychological tests was administered.The low dose produced generalized impairment of all mental processes (concept formation, memory, tactile form discrimination and motor function) and the effect was generalized to all modalities. The high dose resulted in more extensive impairment, again generalized.The drug effects noted were explained in terms of generalized impairment of central integrative processes. The effects of marijuana on learning as well as memory were explained in terms of impaired output (recall), but the impairment was transient.
本研究将81名非初治受试者分为低剂量组和高剂量组，让他们接受四种实验条件（大麻/大麻、大麻/安慰剂、安慰剂/大麻和安慰剂/安慰剂），分两个阶段进行，中间间隔约一周。低剂量为4.8毫克Δ⁹-四氢大麻酚，一小时后再服用2.4毫克。高剂量为9.1毫克，一小时后再服用4.5毫克。进行了一系列神经心理学测试。低剂量导致所有心理过程（概念形成、记忆、触觉形态辨别和运动功能）普遍受损，且这种影响涉及所有感觉模式。高剂量导致更广泛的损伤，同样具有普遍性。所观察到的药物效应是根据中枢整合过程的普遍受损来解释的。大麻对学习和记忆的影响是根据输出（回忆）受损来解释的，但这种损伤是短暂的。
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