Hycanthone analogs: dissociation of mutagenic effects from antischistosomal effects.
作者信息
Hulbert P B, Bueding E, Hartman P E
出版信息
Science. 1974 Nov 15;186(4164):647-8. doi: 10.1126/science.186.4164.647.
PMID:4413726
Abstract
N-Oxidation at the diethylamino group of hycanthone, of lucanthone, and of two chlorobenzothiopyranoindazoles resulted in a marked reduction in mutagenic activity, while antischistosomal activity was retained or even enhanced. Introduction of chlorine into the 8-position of benzothiopyranoindazoles reduced acute toxicity but had no effect on chemnotherapeutic potency. These dissociations of biological activities indicate that safer antischistosomal compounds of this class can be developed.
摘要
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