前列腺素E1和吲哚美辛对胎儿及新生羔羊肠系膜动脉对去甲肾上腺素反应的影响。

Effects of prostaglandin E1 and indomethacin on fetal and neonatal lamb mesenteric artery responses to norepinephrine.

作者信息

Yabek S M, Avner B P

出版信息

Prostaglandins. 1979 Feb;17(2):227-33. doi: 10.1016/0090-6980(79)90042-x.

Abstract

The effects of prostaglandin E1 (PGE1) and indomethacin on isolated fetal and neonatal lamb mesenteric artery responses to norepinephrine were investigated. PGE1 (1.5 micrometer) significantly reduced vasoconstriction responses to 0.5 to 5 micrometer norepinephrine. Indomethacin (1 micrometer) markedly potentiated the constrictor effects of 0.5 to 10 micrometer norepinephrine. PGE1 prevented the potentiating effect of indomethacin. Neither PGE1 nor indomethacin altered basal muscle tension. These results suggest that endogenous PGs modify adrenergic responses in the isolated mesenteric arteries of preterm and newborn lambs.

摘要

研究了前列腺素E1（PGE1）和吲哚美辛对离体胎儿和新生羔羊肠系膜动脉对去甲肾上腺素反应的影响。PGE1（1.5微摩尔）显著降低了对0.5至5微摩尔去甲肾上腺素的血管收缩反应。吲哚美辛（1微摩尔）显著增强了0.5至10微摩尔去甲肾上腺素的收缩作用。PGE1可防止吲哚美辛的增强作用。PGE1和吲哚美辛均未改变基础肌肉张力。这些结果表明，内源性前列腺素可改变早产和新生羔羊离体肠系膜动脉中的肾上腺素能反应。