Gréen K, Svanborg K
Prostaglandins. 1979 Feb;17(2):277-82. doi: 10.1016/0090-6980(79)90048-0.
Several hours following administration of long acting vaginal suppositories containing 3.0 mg of 15-methyl-PGF2 alpha for interruption of second trimester pregnancies there is an up to 10-fold increase in endogenous production of PGE2 and PGF2 alpha before abortion as reflected by gas chromatographic-mass spectrometric determination of the major plasma metabolites of PGE2 and PGF2 alpha. The data suggest that this increased formation of endogenous prostaglandins contributes to the induced uterine activity during the latter part of the abortion process.
在使用含3.0毫克15-甲基-PGF2α的长效阴道栓剂终止中期妊娠数小时后，通过气相色谱-质谱法测定PGE2和PGF2α的主要血浆代谢物发现，流产前内源性PGE2和PGF2α的产生增加了多达10倍。数据表明，内源性前列腺素的这种增加形成有助于流产过程后期诱发子宫活动。
