黄体溶解前列腺素。合成与生物活性。

Luteolytic prostaglandins. Synthesis and biological activity.

作者信息

Bartmann W, Beck G, Lerch U, Teufel H, Schölkens B

出版信息

Prostaglandins. 1979 Feb;17(2):301-11. doi: 10.1016/0090-6980(79)90050-9.

Abstract

Analogues of PGF2 alpha with enhanced luteolytic activity were synthesized using the Corey synthesis. The luteolytic activity of the new prostaglandins was tested in the hamster. In addition the smooth muscle activity of the new compounds was compared with that of PGA2 on the longitudinal strip of rat stomach fundus. Structure-activity relationships in the new series of 17,18,19,20-tetranor-16-thienyl-oxy-PGF2 alpha are discussed.

摘要

使用科里合成法合成了具有增强黄体溶解活性的PGF2α类似物。在仓鼠身上测试了这些新前列腺素的黄体溶解活性。此外，还将这些新化合物的平滑肌活性与PGA2在大鼠胃底纵行肌条上的活性进行了比较。讨论了新的17,18,19,20-四去甲-16-噻吩基氧基-PGF2α系列的构效关系。