Francis K T, Hamrick M E
Res Commun Chem Pathol Pharmacol. 1979 Jan;23(1):69-80.
The effect of dantrolene sodium, a skeletal muscle relaxant, on the hepatic MFO system has been investigated. The dantrolene produces a dose related inhibition of the system. Single doses of 100 mg/kg and accumulative doses up to 125 mg/kg prolong pentobarbital sleeping time and decrease the rate of aminopyrine N-demethylation without altering cytochrome P450 content. However, single doses of 400 mg/kg and accumulative doses of 500 mg/kg do cause a decrease in cytochrome P450 content as part of the dantrolene induced inhibition of the hepatic MFO system.
已对骨骼肌松弛剂丹曲林钠对肝脏混合功能氧化酶（MFO）系统的作用进行了研究。丹曲林对该系统产生剂量相关的抑制作用。100毫克/千克的单次剂量和高达125毫克/千克的累积剂量可延长戊巴比妥睡眠时间，并降低氨基比林N-去甲基化速率，而不会改变细胞色素P450含量。然而，400毫克/千克的单次剂量和500毫克/千克的累积剂量确实会导致细胞色素P450含量下降，这是丹曲林诱导的肝脏MFO系统抑制作用的一部分。
