肥胖鸡主要组织相容性（B）位点与自身免疫性甲状腺炎之间的关系。
Relation between the major histocompatibility (B) locus and autoimmune thyroiditis in obese chickens.
作者信息
Bacon L D, Kite J H, Rose N R
出版信息
Science. 1974 Oct 18;186(4160):274-5. doi: 10.1126/science.186.4160.274.
PMID:4415530
Abstract
Obese strain chickens develop circulating autoantibodies to thyroglobulin and lymphocytic infiltration of their thyroids during aging. Two alleles, B(1) and B(4), are found with high gene frequency at the major histocompatibility (B) locus. Greater pathology and higher antibody titers are observed in B(1)B(1) and B(1)B(4) birds than in their B(4)B(4) siblings.
摘要
肥胖品系鸡在衰老过程中会产生针对甲状腺球蛋白的循环自身抗体，并出现甲状腺淋巴细胞浸润。在主要组织相容性（B）位点发现了两个等位基因B(1)和B(4)，其基因频率较高。与B(4)B(4)的同胞相比，B(1)B(1)和B(1)B(4)的鸡表现出更严重的病变和更高的抗体滴度。
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