Wiggins H S, Pearson J R, Walker J G, Russell R I, Kellock T D
Gut. 1974 Aug;15(8):614-21. doi: 10.1136/gut.15.8.614.
Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid. It was found that in general the percentage of OHSA in the faecal fatty acids increased with increasing fat output. Thus most patients excreting less than 20 g of fat per day had less than 5% OHSA while those with greater steatorrhoea had levels of 6 to 23%. Exceptions were patients with mild steatorrhoea with ileal disease, ileal resections, or small intestinal bacterial colonization, who had more than 5% OHSA whilst patients with colonic resection had much lower levels of OHSA than otherwise found. It is impossible to determine whether OHSA had a specific cathartic action from this study since the data implicated total fatty acids to the same extent.
在正常饮食期间，从87名患有各种胃肠疾病诊断的患者和12名对照受试者中收集了三天的粪便。测量了粪便重量、总脂肪酸和羟基硬脂酸（OHSA）的比例。所有患者都有一些易于检测到的羟基硬脂酸。研究发现，一般来说，粪便脂肪酸中OHSA的百分比随着脂肪排出量的增加而增加。因此，大多数每天排出少于20克脂肪的患者，其OHSA含量低于5%，而脂肪泻更严重的患者，其OHSA水平为6%至23%。例外情况是患有轻度脂肪泻的回肠疾病、回肠切除术或小肠细菌定植的患者，其OHSA含量超过5%，而结肠切除术患者的OHSA水平远低于其他情况。由于该数据在相同程度上涉及总脂肪酸，因此无法从这项研究中确定OHSA是否具有特定的导泻作用。
