对兔子巴比妥类麻醉死亡的防护作用。
Protection against barbiturate anaesthesia death in rabbits.
作者信息
Coates A L, Hogg J C, Thurlbeck W M
出版信息
Br J Exp Pathol. 1974 Jun;55(3):228-32.
In rabbits given intravenous pentobarbitone sodium until apnoea or severe hypoventilation ensued, chest compression caused a reversible increase in minute ventilation with a resulting drop in arterial PCO. The effect of this was most marked for the first 10 minutes, after which the animal became progressively less dependent on this reflex for respiration although still deeply anaesthetized. This reflex respiration appears to be independent of arterial PCO as well as the CO concentration in the inspired gas. Utilization of this reflex has greatly simplified the use of barbiturate anaesthesia in rabbits in our laboratory.
给兔子静脉注射戊巴比妥钠直至出现呼吸暂停或严重通气不足，胸部按压可使分钟通气量可逆性增加，从而导致动脉血二氧化碳分压下降。这种效应在最初10分钟最为明显，之后尽管动物仍处于深度麻醉状态，但对这种呼吸反射的依赖程度逐渐降低。这种反射性呼吸似乎与动脉血二氧化碳分压以及吸入气体中的二氧化碳浓度无关。在我们实验室，利用这种反射极大地简化了巴比妥类麻醉在兔子中的应用。
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