Goldberg M S, Milic-Emili J
J Appl Physiol Respir Environ Exerc Physiol. 1977 Jun;42(6):845-51. doi: 10.1152/jappl.1977.42.6.845.
Using the airway occlusion pressure technique, control of breathing was studied in unanesthetized and anesthetized newborn rabbits breathing various gas mixtures under steady-state conditions. Independent of the gas mixture breathed, barbiturate anesthesia resulted in a reduction of ventilation. This was not due to a change in inspiratory drive since for each gas mixture breathed the pressure generated by the inspiratory muscles 0.3 s after the onset of the occluded inspiration (P0.3) remained virtually unchanged, nor could this be attributed to changes in respiratory mechanics as indicated by the fact that the relation between P0.3 and V0.3 (the volume generated 0.3 s after onset of the immediately preceding unoccluded inspiration) did not change. On the other hand, during anesthesia inspiratory time was slightly shortened as a result of a change in both central (bulbopontine) and peripheral (volume-related vagal reflex) modulation, while expiratory duration was markedly prolonged. This disproportionate increase in expiratory duration with respect to inspiratory duration was responsible for most of the depression of ventilation found in the newborn rabbits during barbiturate anesthesia.
采用气道阻断压力技术，在稳态条件下，对未麻醉和麻醉的新生兔呼吸各种气体混合物时的呼吸控制进行了研究。巴比妥类麻醉导致通气量减少，这与所呼吸的气体混合物无关。这并非由于吸气驱动力的改变，因为对于所呼吸的每种气体混合物，在阻断吸气开始后0.3秒时吸气肌产生的压力（P0.3）基本保持不变，也不能归因于呼吸力学的改变，这一事实表明P0.3与V0.3（在前一次未阻断吸气开始后0.3秒产生的容积）之间的关系并未改变。另一方面，在麻醉期间，由于中枢（延髓脑桥）和外周（与容积相关的迷走神经反射）调节的改变，吸气时间略有缩短，而呼气持续时间明显延长。呼气持续时间相对于吸气持续时间的这种不成比例的增加是巴比妥类麻醉期间新生兔通气抑制的主要原因。
