病毒引发癌症的介绍。
Introduction to virus-caused cancers.
作者信息
Temin H M
出版信息
Cancer. 1974 Oct;34(4 Suppl):suppl:1347-52. doi: 10.1002/1097-0142(197410)34:8+<1347::aid-cncr2820340803>3.0.co;2-l.
Members of four different groups of animal viruses are known to cause cancer in animals. (Only two of them, the leukoviruses and herpesviruses, cause cancer in nonlaboratory situations.) All the members of these groups of viruses form integrated viral DNA in infected cells. However, the efficiencies with which they cause cancer vary by over a dozen orders of magnitude. These differences in efficiency are a result of differences in efficiency of formation and expression of the genes for neoplastic transformation. Four models of mechanisms for formation of the genes for neoplastic transformation are presented. Two involve the formation of new DNA sequences. No efficient human cancer‐causing viruses are known. Therefore, it is proposed that human cancer is a result of formation of the genes for neoplastic transformation by misevolution of a normal cellular information transferring process. This misevolution is caused by chemicals, physical agents, or viruses.
已知四种不同的动物病毒组的成员可在动物体内引发癌症。（其中只有两种，即白血病病毒和疱疹病毒，会在非实验室环境中引发癌症。）这些病毒组的所有成员在受感染细胞中形成整合的病毒DNA。然而，它们引发癌症的效率相差超过十二个数量级。这些效率差异是肿瘤转化基因形成和表达效率差异的结果。本文提出了四种肿瘤转化基因形成机制的模型。其中两种涉及新DNA序列的形成。目前还没有已知的高效致人类癌症的病毒。因此，有人提出人类癌症是正常细胞信息传递过程发生错误进化而形成肿瘤转化基因的结果。这种错误进化是由化学物质、物理因素或病毒引起的。
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